The latter 2 features were characterized by clear discrete vacuoles and yellow granular periodic acid-Schiff-positive pigment within Purkinje cell perikarya
, interpreted to be lipofuscin, or shrunken angular hypereosinophilic neurons (Fig 4B) with pyknotic nuclei.
were gathered in clusters, mainly associated with the graft-host interface.
(2) Giant ganglia, defined as enlarged ganglia containing large numbers of perikarya
, have been previously described in the literature.
The number of SP-, CGRP-, and L-ENK-like immunoreactive (LI) enteric neurons was expressed as a percentage of the total number of Hu C/D-positive perikarya
. At least 700 Hu C/D-labelled cell bodies of intramural ganglia of each part of the stomach were examined.
These large cholinergic terminals form C-type synapses on motoneuronal perikarya
and proximal dendrites and utilize M2 muscarinic receptors for acetylcholine in the postsynaptic membrane [41-46].
Rab5 mainly concentrated in the neuronal soma, particularly in the perikarya
, while Rab7 was located in the neuronal submembrane region and proximal neurites.
A recent report by Barreiro-Iglesias and Shifman (2015) has shown that caspase activation in the cell perikarya
of bad-regenerating descending neurons of lampreys is preceded by the initial activation of caspases in the axotomized axons at the lesion site within the first hours after the injury.
Reports of substantial neocortical deficits in choline acetyltransferase (ChAT), the enzyme responsible for the synthesis of acetylcholine (ACh), discoveries of reduced choline uptake, ACh release, and loss of cholinergic perikarya
from the nucleus basalis of Meynert, along with the emerging roles of ACh in learning and memory, led to the "cholinergic hypothesis of AD" .
They largely accumulate in the perikarya
of nerves and glial cells and are found in cells of the brain and the eye as well as in skin, muscle, and many other tissues.
Nerve fibres originate from perikarya
located in the sympathetic superior cervical ganglion and the parasympathetic sphenopalatine and optic ganglion innervate the gland .
The capillary walls appear fused to the membranes of neuronal perikarya
. In the Parkinsonian SNc since the close contact between nigral neuron and the capillary is lost (Issidorides, 1971).
In presented study, bacterial endotoxin lowered GnRH mRNA level in the POA, where more than half of all GnRH perikarya
are located .