If cell growth represents simply an increase in the perikaryal
area, the ratio of membrane protein to total protein would fall in parallel with the decline in the surface/volume ratio (volume increases with the cube of the perikaryal
radius, whereas surface area increases with the square of the radius).
This eventually results in two distinct cell clusters instead of a repetitive perikaryal
arrangement in the late sipunculan larva (Kristof et al, 2008; Wanninger et al, 2009).
Al-Abdulla AN, Leo JM (1998) Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal
mitochondria and oxidative damage to the nucleus.
Typically, the localization of [Beta]III was diffuse within the individual tumor cells and was distributed equally in both the perikaryal
cytoplasm and in major fibrillated cell processes (Figure 2, a through f).
Typical AD neuropathological lesions include perikaryal
neurofibrillary tangles, which consist of paired helical filaments.
Arsenic inhibits neurofilament transport and induces perikaryal
accumulation of phosphorylated neurofilaments: roles of JNK and GSK-3beta.
Immunohistochemically, the cells with ganglionic features showed focal perikaryal
staining for synaptophysin and chromogranin, whereas many of the spindled cells were immunoreactive for GFAE Immunoreactivity for MIB-1 was less than 2% of tumor nuclei, whereas that for p53 was close to 40%.