Besides, the study provided the analysis of pathological changes in neurons of the hippocampal CA1 region such as the presence of pyknotic hyperchromic neurons, shadow cells, neurons with focal hyperchromia of perikaryon
, neuronal disaggregation, and partial destruction of the cellular layer.
The normal cerebral cortex cells had pyramidal or spherical perikaryon
with large nuclei where the cells were arranged in a uniform pattern (Figures 5(a), 5(b), and 5(c)).
In addition, the immunostaining highlighted cells with short processes stemming from the round perikaryon
in a spoke wheel-like fashion (Figure 3, panel D).
Although in this study the mechanisms underlying the reductions in the number of cerebellar granule cells and decrease in the size of perikaryon
of purkinje cells were not investigated, however, it is known that glucocorticoids easily cross the blood-brain barrier and acts on CNS.
Dowson (1998) observed an increase in the mean total area of discrete regions of lipopigment in a Purkinje cell perikaryon
as age advances.
Aggregation of pigment perikaryon
and dispersion throughout the cytoplasm are the bases of the motile activities of an ordinary dendritic light-absorbing chromatophore.
1966) Preparation and characterization of nerve cell perikaryon
from rat cerebral cortex.
Old PCs showed a remarkable loss of Nissl granules in the perikaryon
We also assessed the expression and localization of mOatp1b2 in neurons via immunocytochemistry, which revealed immunopositive staining in membranes of the perikaryon
as well as in neurites of cultured cells (Figure 4G).
Al induced tangles are found in the perikaryon
and proximal parts of the dendrites and axon (50,51).
Axon injury leads to prominent cellular responses, including enhanced synthesis of RNA and protein in the neuronal perikaryon
, and proliferation of reactive Schwann cells (70).
Intracellular A[Beta] immunostaining of hippocampal and cortical neurons, detected with the A[Beta]1-28 and A[Beta]40 (R163) antibodies, was present in all DS cases, including subjects as young as 1 year This immunostaining had a distinct vesicular pattern and was strongest in the perikaryon
(Figure 1), but was also present in neuronal processes.