One author disclosed financial ties to the pharmaceutical industry and reported having a patent for peripheral perineural
The recurrence rate for carcinomas with perineural
invasion--a high-risk feature--was 23.28% for standard excision, but just 9.74% for CCPDMA in the meta-analysis of medical literature from 1993 to 2017.
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On histopathology there was an intense lymphocytic, perineural
infiltration and focal granulomatous inflammation, around the nerve.
All surgical specimens were examined in detail for certain pathologic features including presence of extraprostatic invasion, perineural
invasion, positive surgical margin, seminal vesicle invasion and Gleason score.
Demographics and clinicopathologic data, including age, sex, adjuvant chemotherapy, cancer location, vascular invasion, perineural
invasion (PNI), primary tumor size, tumor differentiation, preoperative colonic obstruction/perforation, the total count of lymph nodes examined, and year of surgery were provided from chart reviews of patients with CRC from one oncology center in Turkey.
Loss of "basement membrane" or "basal cell layer loss" and perineural
and vascular invasion were identified as aggressive features for PCa.
Osman et al (2013) in which prostatic adenocarcinoma cases were histologically classified into 24 cases (34.8%) of "low grade" carcinomas (with Gleason score of 6), 18 cases (26%) of "intermediate grade" carcinomas (with Gleason score of 7) and 27 cases (39%) of "high grade" carcinomas (with Gleason score of 8 and 9).23 The perineural
invasion (PNI) is the presence of prostate cancer tracking around or along the nerve within the perineural
Nodular and superficial BCC (sBCC), as well as BCCs with lack of perineural
invasion are considered to be low-risk due to their low recurrence rate (6).
A multivariate analysis identified R1 resection, lymph node metastases, T stage of three or higher, and perineural
invasion as independent prognostic factors for poor overall survival (14).
Instead, the mainstay of imaging is delineating the extent of the disease preoperatively, which includes evaluating deep or superficial lobe involvement, extraglandular invasion of adjacent structures, perineural
invasion, and cervical lymph node metastases.
Variables in the model included age (as a continuous variable), pathologic tumor size according to TNM classification (T1, T2, T3), pathological nodal status according to TNM classification (N1, N2, N3), histologic grade, histologic type of BC (ductal, lobular and other), presence of lymphovascular and perineural
invasion, hormone receptor (ER- and PgR positive and negative), HER2 status (positive and negative), TNBC, type of surgery and presence of comorbidities.