Multiple cranial nerve involvement is usually considered as an indicator of basilar meningitis and is thought to be a result of compression caused by oedematous brain or meningeal inflammation resulting in perineuritis
. Third, fourth, sixth, and seventh nerves are the commonest nerves to get affected  and the involvement of the hypoglossal nerve is very rarely described in literature.
First described in 1883, optic perineuritis
is an uncommon orbital inflammatory diseaseinvolving theoptic nervesheath; although it tends to mimic demyelinating optic neuritis, there are some clinical features that help to distinguish the two .
This resolved two weeks later and was postulated to be due to perineuritis
causes intense pain along the nerve distribution.
En esta etapa, hay anormalidades neurologicas, caquexia, anasarca, coma y muerte acompanada de engrosamiento de nervio periferico por material mixoide y edema, perineuritis
y glomerulonefritis membranosa.
(13) in a study on neuro-ophthalmic findings in acquired immunodeficiency syndrome reported abnormalities in the form of perineuritis
, papilledema, papillitis, retrobulbar neuritis, and optic atrophy in about 6% of the patients.
Entre sus causas estan perineuritis
optica, neuropatia optica isquemica y procesos infiltrativos del nervio optico, como sarcoidosis.
Classically the infection produces a ring infiltrate and exquisitely painful radial perineuritis
, but in reality AK can present with a wide variety of clinical findings and objective confirmation of the diagnosis can be elusive.
Typically, PNS-Lyme disease is associated with transverse myelitis and patchy multifocal axonal loss with epineural perivascular inflammatory infiltrates or perineuritis
Failure to locate worms may relate to the body site and/or killed worms, or host inflammatory response (i.e., meningitis and perineuritis