In the controls and treated rats, the longitudinal sections of sciatic nerve show parallel bundles of nerve fibres encased by perineurium
A peripheral nerve is composed of axon, myelin, endoneurium, fascicle, perineurium
Perineural invasion is defined as extension of tumor into the perineural plane between nerve bundles and the perineurium
. For this data set, either intratumoral or extratumoral perineural invasion is regarded as a positive finding.
The spaces between the fibroblast-like cellular sheets and perineurium
contained accumulated endoneurial oedema, in addition to some of the endoneurial macrophages carrying degenerated myelin (Fig.
is a sheath that surrounds the individual fascicles, of which there are 3 possible patterns: monofascicular (consisting of a single large fascicle), as in the interscalene brachial plexus, which exposes the patient to a high risk of injury when there is an intraneural injection; oligofascicular (a few fascicles of various sizes), and polyfascicular (many fascicles, some of various sizes).
Sural nerve biopsy demonstrated mononuclear cell infiltration, especially around the vessels and the perineurium
The amphicrine AR42J cells were slowly inoculated (0.5 x [10.sup.6]) in the perineurium
sheath of the SN of two successive groups of rats (n = 5 each) using a 25 [micro]L Hamilton[R] GASTIGHT[R] syringe, 1702LT Series (Sigma-Aldrich Chemie GmbH) and watched for 40 days.
NF-[kappa]B activation, which is involved in the pathogenesis of diabetic complications, especially DPN , has been identified in the endoneurium, epineurial vessels and perineurium
in sural nerve biopsies of overt diabetic subjects .
Delayed clinical improvement prompted a biopsy and histopathological examination of the medial antebrachial nerve of the left forearm during the 7th week of illness which demonstrated an inflammatory neuropathy characterized by inflammatory changes in the endoneurium, perineurium
, and epineurium.
Intraoperative findings suggested that administration of over 1 ml PRP infiltration results in pressure on the nerve fascicles in the perineurium
because 1 ml of PRP infiltration causes the digital nerve width to increase to twice as large as that before injection.
It is suspected that cancer cells may reach the leptomeninges through hematogenous spread, direct invasion from parenchymal lesions, or spread along the perineurium
from cranial or spinal nerves.
The clinical administration of peripheral nerve injury is still the classic epineurium or perineurium
neurorrhaphy that dates back to more than 100 years ago. However, efficient anastomosis of homogeneous nerve fibers in bilateral neural stumps cannot be achieved merely through these two surgical methods.