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Adj.1.perirhinal - near the nose
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Environmental novelty is associated with a selective increase in Fos expression in the output elements of the hippocampal formation and the perirhinal cortex.
They showed that the memory recovery was promoted by the H3 receptor inverse agonists through upregulation of histamine release in the brain, the following activation of histamine H2 receptors and increased spontaneous activity in perirhinal cortex neurons.
Such pattern of alcohol exposure also resulted in the neuron loss in the olfactory, entorhinal, perirhinal, and piriform cortexes and the increased amount of microglia [49].
Some assays (e.g., novel object location) are almost exclusively dependent on the hippocampus [45], while others (contextual fear conditioning or novel object recognition) also involve additional brain regions such as the amygdala and perirhinal cortex, respectively [45-47].
Lesions on the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition.
Amaral, "Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents," Journal of Comparative Neurology, vol.
Heinemann, "Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats," Neurobiology of Disease, vol.
The BLA also projects to different cortical areas, including the infra- and prelimbic mPFC, ACC, and perirhinal and insular cortices [51, 61-67].
The postrhinal cortex is the area involved in spatial memory [41], while the entorhinal cortex receives spatial and nonspatial information from the postrhinal and perirhinal cortex, respectively [42].
When rodents explore novel objects the pathway from the perirhinal cortex to lateral entorhinal cortex and then to the dentate gyrus and CA3 is engaged, whereas the pathway from the perirhinal cortex to lateral entorhinal cortex and then to CA1 is involved when familiar object s are explored [41].
En 1991, Squire y Zola-Morgan [19] expandieron la distincion entre memoria declarativa y memoria procedimental, propusieron que la memoria declarativa representa una coleccion de habilidades dependientes del sistema de memoria del lobulo temporal medial [LTM], conjunto de estructuras conectadas anatomicamente que incluye las cortezas entorhinal, perirhinal y parahipocampal y el hipocampo.