pernicious anemia


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Related to pernicious anemia: iron deficiency anemia, aplastic anemia

pernicious anemia

n.
A severe anemia most often affecting older adults, caused by failure of the stomach to absorb vitamin B12 and marked by a decrease in number and an increase in the size of red blood cells, by gastrointestinal disturbances, and by lesions of the spinal cord.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

perni′cious ane′mia


n.
a severe anemia associated with inadequate intake or absorption of vitamin B12, characterized by defective production of red blood cells.
[1870–75]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.

pernicious anemia

Anemia is the lack of hemoglobin (oxygen- carrying part of blood). Pernicious anemia is due to a lack of vitamin B12, and is often caused by an autoimmune disorder.
Dictionary of Unfamiliar Words by Diagram Group Copyright © 2008 by Diagram Visual Information Limited
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.pernicious anemia - a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12)
megaloblastic anaemia, megaloblastic anemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia
metaplastic anaemia, metaplastic anemia - pernicious anemia in which the various formed elements in the blood are changed
anemia, anaemia - a deficiency of red blood cells
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Since one sign of pernicious anemia is extreme fatigue, the notion arose that [B.sub.12] injections could make weary people feel more energetic, even if they don't have a [B.sub.12] deficiency.
[16] studied 40 patients of pernicious anemia all were having chronic atrophic gastritis.
For decades, it has been taught that vitamin [B.sub.12] deficiency in patients with pernicious anemia is due to poor [B.sub.12] absorption caused by a lack of intrinsic factor, and that replacement must be given intramuscularly.
DISCUSSION: Pernicious anemia is the end stage of an autoimmune disorder in which parietal cell antibodies against [H.sup.+][K.sup.+]- adenosine triphosphates cause loss of gastric parietal cell.
In our study, no data concerning pernicious anemia could be provided due to non-availability of appropriate laboratory tests like Schilling test, anti-intrinsic factor antibody and others for exclusion of pernicious anemia14.
Patients with gastric adenocarcinoma are approximately three times more likely to have pernicious anemia than are the general population.
We report a case in which an analytical problem within the hninulite 2000 assay [Diagnostic Products Corporation (DPC)] led to a falsely increased Cbl result for a patient presenting with classic hematologic and biochemical features of pernicious anemia.
and Canadian authorities decided against boosting fortification to achieve the optimal levels needed for prevention of neural tube defects, because high levels of folic acid can mask pernicious anemia caused by vitamin [B.sub.12] deficiency in the elderly, leading to irreversible neural damage, especially peripheral neuritis.
Pernicious anemia is the absolute deficiency of intrinsic factor.
I had a similar problem with mouth sores in '98, and in 1999 a Kathleen Mutach wrote, "Bless Vitamin [B.sub.12]!" I finally got a doctor to do a blood [B.sub.12] analysis on me, and I was diagnosed with pernicious anemia. Since then I have taken a [B.sub.12] shot once a month and will continue for the rest of my life.
A blood count revealed an anti-intrinsic factor antibody however, and pernicious anemia was diagnosed.
Each tablet not only includes the necessary 400 mcg of folate, but also 400 mcg of vitamin [B.sub.12]--which has been shown to prevent a rare but dangerous malady, pernicious anemia.