The present Competitive Intelligence Report about PPAR Agonists provides a competitor evaluation in the field of peroxisome
proliferator-activated receptor targeting small molecule agonists for treatment of type 2 diabetes and/or dyslipidemia as of August 2010.
lead to hyperactivity of the peroxisome
proliferator-activated receptor gamma (PPAR?
Pioglitazone is less potent agonist of the peroxisome
proliferator-activated receptor gamma (PPAR-g) than rosiglitazone, but is effective in reducing both fasting blood glucose and glycatedhaemoglobin (HbA1c) level.
Lipofen (fenofibrate capsules) is a peroxisome
proliferator receptor alpha (PPARa) activator indicated as an adjunct to diet: to decrease elevated LDL-C, Total-C, TG and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidaemia and for treatment of adult patients with severe hypertriglyceridemia.
Alexander and colleagues confirmed that alpha-lipoic acid stimulates peroxisome
proliferator-activated receptor gamma co-activator 1-alpha (PGC1-alpha), which is known to control some aspects of how muscles respond to exercise.
proliferator-activated receptors (PPAR) are members of the nuclear receptor superfamily and was first identified in xenopus (Krey et al.
has identified a molecular culprit, called peroxisome
proliferator-activated receptor delta (PPAR delta), which, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.
1739) investigated mechanisms by which AhR activation affects glucose metabolism by examining glucose tolerance, insulin resistance, expression of peroxisome
proliferator-activated receptor-[alpha] (PPAR-[alpha]) and genes affecting glucose metabolism or fatty acid oxidation, and clock gene rhythms in wild type (WT) and AhR-deficient [knockout (KO)] mice.
The researchers noted in the paper that "strong clinical evidence has shown the ability of statins to stabilize plaque, along with positive results for aspirin and other antiplatelet agents, beta-blockers, and renin-angiotensin-aldosterone system inhibitors" and the presence of "some evidence showing plaque stabilization abilities for peroxisome
proliferator activated receptor (PPAR) agonists, niacin, omega-3 fatty acids, and some HDL-raising therapies.
Stephen is supporting Claire House after the Wirral Hospice cared for a close family friend's son, Harvey Jones Lanagan, who died from Peroxisome
Biogenesis disorder, aged just four.
The mRNA expressions of peroxisome
proliferator-activated receptor (PPAR) [alpha], diacylglycerol acyltransferase (DGAT), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and cholesterol 7[alpha]-hydroxylase (CYP7A) in mouse hepatic tissue or cultured hepatocytes were determined by reverse transcription polymerase chain reaction (RT-PCR).
proliferator-activated receptor, gamma (PPARG)  is a member of the steroid hormone receptor superfamily and is a critical transcriptional regulator of adipogenesis.