Liver samples (200 mg) were prepared for pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), peroxisome
proliferators activated receptor-[alpha] (PPAR-[alpha]), and glucose transporter-2 (GLUT-2).
The transcriptional coactivator peroxisome
proliferator-activated receptor ?
has identified a molecular culprit, called peroxisome
proliferator-activated receptor delta (PPAR delta), which, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.
Researchers also found that long-term feeding of a HF diet to mice caused obesity and glucose intolerance with increased fat volume, fat size and peroxisome
proliferator-activated receptor-gamma (PPAR[gamma]) protein.
Twenty-four hours after the last training bout a subgroup of mice (n = 9-11/group) were euthanized, and brain (brain stem, cerebellum, cortex, frontal lobe, hippocampus, hypothalamus, and midbrain) and muscle (soleus) tissues were isolated for analysis of mRNA expression of peroxisome
proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1 [alpha]), Silent Information Regulator T1 (SIRT1), citrate synthase (CS), and mitochondrial DNA (mtDNA) using RT-PCR.
Abbreviations: Glut-4, glucose transporter-4; PPAR, peroxisome
proliferator-activated receptors; RT PCR, real time polymerase chain reaction; MEM, minimum essential medium.
TFZ has been identified as an activator of peroxisome
proliferator-activated receptor gamma ([PPAR.
Given the ability of peroxisome
proliferator-activated receptor [gamma] coactivator 1[alpha] (PGC-1[alpha]) to activate components of the fasting response in the liver, we investigated the role of this transcriptional factor by infecting mouse primary hepatocytes for 24 h at a multiplicity of infection of 25 with adenovirus producing either PGC-1[alpha] or green fluorescent protein as a control (2).
We found that massage activated the mechanotransduction signaling pathways focal adhesion kinase (FAK) and extracellular signal-regulated kinase 1/2 (ERK1/2), potentiated mitochondrial biogenesis signaling [nuclear peroxisome
proliferator-activated receptor  coactivator 1 (PGC-1)], and mitigated the rise in nuclear factor  B (NFB) (p65) nuclear accumulation caused by exercise-induced muscle trauma.
Proliferator Activated Receptor gamma (PPARy) is the key regulator of the immune and inflammatory response.
has announced the positive results from a successfully completed Phase 1b clinical study for DB959, its peroxisome
proliferator activated receptor (PPAR)-delta/gamma agonist, a non-TZD oral drug in development for the treatment of type 2 diabetes.
His son Harvey suffered from the rare metabolic condition peroxisome
DEDICATED: Tony and biogenesis disorder and was just four when he died last year.