peroxisome


Also found in: Medical, Encyclopedia, Wikipedia.

per·ox·i·some

 (pə-rŏk′sĭ-sōm′)
n.
A cell organelle containing a large number of enzymes, including catalase and oxidase, that break down long-chain fatty acids and other organic molecules. The hydrogen peroxide produced by these reactions is also broken down within the peroxisome.


per·ox′i·som′al (-sō′məl) adj.

peroxisome

(pəˈrɒksɪˌsəʊm)
n
(Biochemistry) biology a type of organelle present in most eukaryotic cells that carry out oxidative reactions, such as oxidation of alcohol in the liver
Mentioned in ?
References in periodicals archive ?
The present Competitive Intelligence Report about PPAR Agonists provides a competitor evaluation in the field of peroxisome proliferator-activated receptor targeting small molecule agonists for treatment of type 2 diabetes and/or dyslipidemia as of August 2010.
Pioglitazone is less potent agonist of the peroxisome proliferator-activated receptor gamma (PPAR-g) than rosiglitazone, but is effective in reducing both fasting blood glucose and glycatedhaemoglobin (HbA1c) level.
Lipofen (fenofibrate capsules) is a peroxisome proliferator receptor alpha (PPARa) activator indicated as an adjunct to diet: to decrease elevated LDL-C, Total-C, TG and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidaemia and for treatment of adult patients with severe hypertriglyceridemia.
Alexander and colleagues confirmed that alpha-lipoic acid stimulates peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1-alpha), which is known to control some aspects of how muscles respond to exercise.
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear receptor superfamily and was first identified in xenopus (Krey et al.
has identified a molecular culprit, called peroxisome proliferator-activated receptor delta (PPAR delta), which, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.
1739) investigated mechanisms by which AhR activation affects glucose metabolism by examining glucose tolerance, insulin resistance, expression of peroxisome proliferator-activated receptor-[alpha] (PPAR-[alpha]) and genes affecting glucose metabolism or fatty acid oxidation, and clock gene rhythms in wild type (WT) and AhR-deficient [knockout (KO)] mice.
The researchers noted in the paper that "strong clinical evidence has shown the ability of statins to stabilize plaque, along with positive results for aspirin and other antiplatelet agents, beta-blockers, and renin-angiotensin-aldosterone system inhibitors" and the presence of "some evidence showing plaque stabilization abilities for peroxisome proliferator activated receptor (PPAR) agonists, niacin, omega-3 fatty acids, and some HDL-raising therapies.
Stephen is supporting Claire House after the Wirral Hospice cared for a close family friend's son, Harvey Jones Lanagan, who died from Peroxisome Biogenesis disorder, aged just four.
The mRNA expressions of peroxisome proliferator-activated receptor (PPAR) [alpha], diacylglycerol acyltransferase (DGAT), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and cholesterol 7[alpha]-hydroxylase (CYP7A) in mouse hepatic tissue or cultured hepatocytes were determined by reverse transcription polymerase chain reaction (RT-PCR).
Peroxisome proliferator-activated receptor, gamma (PPARG) [4] is a member of the steroid hormone receptor superfamily and is a critical transcriptional regulator of adipogenesis.

Full browser ?