including aripiprazole, haloperidol, olanzapine, paliperidone, perphenazine
, quetiapine and risperidone.
10 ( ANI ): New studies in zebrafish have shown that a 50-year-old antipsychotic medication called perphenazine
can actively combat the cells of a difficult-to-treat form of acute lymphoblastic leukemia (ALL).
Cost-Effectiveness of Second-Generation Antipsychotics and Perphenazine
in a Randomized Trial of Treatment for Chronic Schizophrenia.
olanzapine, risperidone, quetiapine, and ziprasidone) against the older typical antipsychotic perphenazine
in 1,493 adults with schizophrenia.
5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine
Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
There are two broad categories of antipsychotics: "first generation" medications such as haloperidol and perphenazine
, and the newer class known as "atypicals," such as risperidone.
Worcester, charged with possession of a class B substance with intent to distribute, amended from possession of cocaine with intent to distribute, sentenced to 2-1/2 years in the House of Correction; possession of perphenazine
, amended from possession of perphenazine
with intent to distribute, sentenced to a concurrent term of 6 months in the House of Correction; selling or possessing an electric stun gun and drug violation near a school or park, dismissed.
Cost-effectiveness of second generation antipsychotics and perphenazine
in a randomized trial of treatment for chronic schizophrenia.
3] Ireland F A, Loch W E, Worthy K, Anthony R V, Effects of bromocriptine and perphenazine
on prolactin and progesterone concentration in pregnant pony mares during late gestation, J Reprod Fertil, 92 (1990) 179.
For a patient who presents for evaluation before pregnancy on a low dose of an atypical antipsychotic as an adjunct to a mood stabilizer, it may make sense to switch to an antipsychotic for which more reproductive safety data are available, such as perphenazine
haloperidol, chlorpromazine, perphenazine
, thorazine, thiothixene).
The CATIE Trial examined the effectiveness of a number of antipsychotics, comparing four second-generation antipsychotics (olanzapine, risperidone, quetiapine and ziprasidone) with perphenazine
, a first-generation antipsychotic.