phage display


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phage display

n.
A method of using genetically modified bacteriophages to make new proteins and replicate selected proteins, enabling the engineering of antibodies and the development of new drugs.

[From the fact that the proteins are displayed on the surface of the bacteriophages .]
References in periodicals archive ?
For the sake of optimizing sdAbs' nonhuman original character that might lead to immunogenicity, Creative Biolabs launched the synthetic human single domain antibody phage display libraries adopting humanized sdAb scaffolds.
The study published in the 'New England Journal of Medicine' identified a highly specific and unique biomarker for the disease by using a variation of "programmable phage display" technology.
The company has a novel and proprietary phage display screening platform that we use to identify Bicycles in an efficient manner.
Esrs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell rna-seq), crispr-cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of ipscs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging.
The potentially game-changing anti-cancer drug is based on SoAP technology, which belongs to the phage display group of technologies.
(193) Phage display technology, which allows for the synthetic expression of different proteins on the surfaces of phages, is another technique of synthetically modifying phages.
Stefan Dubel (Technical University of Braunschweig, Braunschweig, Germany) presented the phage display method as an alternative to completely replace the use of animals for antibody generation.
This technique, called phage display, has been used to fight rheumatoid arthritis, psoriasis and inflammatory bowel diseases.
Sir Greg, 67, who has maintained a record-breaking run for affiliates of Cambridge University, has been jointly awarded the 2018 Nobel Prize in Chemistry, along with Frances Arnold and George Smith, for his pioneering work in using phage display for the directed evolution of antibodies, with the aim of producing new pharmaceuticals.
The Academy in a press release said the other half is jointly shared by George Smith of the US and Sir Gregory Winter of the UK for the 'phage display of peptides and antibodies'.
Smith developed a process called 'phage display' that was then taken up by Sir Gregory P.
According to the statement of the academy, this year's award went with one half to the American scientist Frances H Arnold "for the directed evolution of enzymes," while the other half was jointly shared by American George P Smith, and British Sir Gregory P Winter "for the phage display of peptides, and antibodies."