Cholesterol accumulation by macrophages impairs phagosome
The unstable expression of actin under infection occurs because it is involved in phagosome
formation during early pathogen internalization where actin cytoskeleton remodeling occurs (May & Machesky 2001).
abortus 2308 Iomp10 couldn't inhibit the fusion of the phagosome
2] modulates phagosome
maturation and regulates the innate immune response against Candida albicans.
It is well recognized that certain bacteria inhabiting a vacuole or phagosome
, are able to synthesize some proteins and toxins to form holes in the vacuole membrane of their hosts to escape from these organelles (Van der Meer-Janssen et al.
However, the microorganism can multiply and survive intra-cellularly by inhibiting and counteracting bactericidal effects within the phagosome
This organism has capability to impede with intracellular trafficking by preventing fusion of the BCV with lysosome markers, in order to evade degradation within phagolysosomes by rapid acidification of the phagosome
The c[beta]g gene product (cyclic [beta]-1,2-glucans) interferes with cellular trafficking by acting on lipid rafts found on host cell membranes and preventing the phagosome
lysosome fusion cycle, thereby leading to intracellular survival.
Stow, "Cell biology: A role for the phagosome
in cytokine secretion," Science, vol.
In the macrophage phagosome
, the reaction between nitric oxide (NO*) and superoxide anion ([sup.
Reactive oxygen species are the major antibacterial against Salmonella Typhymurium purine auxotroph in the phagosome
Different phagocyte enzymes are activated or reach optimal activity rates during phagosome
maturation as the phagolysosomal pH decreases from slightly alkaline to acidic (7.