"I'll take the phenacetin
," she promised, "but I hate going to bed early.
Hereditary HbM NADH-MetHb reductase deficiency Acquired Medications Amyl nitrite Benzocaine Dapsone Lidocaine Nitroglycerin Nitroprusside Phenacetin
Phenazopyridine Prilocaine Quinones (chloroquinone, primaquine) Sulfonamides (sulfanilamide, sulfathiazide, sulfapyridine, sulfamethoxazole) Chemical agents Aniline dye derivatives (shoe dyes, inks) Butyl nitrite Chlorobenzene Nitrate-containing foods Isobutyl nitrite Naphthalene Nitrophenol Nitrous gases Silver nitrate Trinitrotoluene Well water nitrates Pediatric Decreased NADH-MetHb reductase activity (<4 months of age) Associated with low birth weight, prematurity, dehydration, acidosis, and diarrhea Table 3.
His mother Sarah died of kidney failure after she took the pain-killer phenacetin
Acylation of 3 to phenacetin
(4, R=Et, R'=Ac) or an analog was conducted by reaction with an acid under microwave irradiation.
The health ministry asked drugmakers Thursday to stop supplying prescription medicines containing phenacetin
, an antifebrile drug and pain killer, which it said carries the risk of serious renal damage, bladder cancer and other ailments.
Yellow is, of course, the normal color, but phenacetin
(found in many pain medications) and the B vitamin riboflavin can also produce a yellow color (bright yellow with large doses of the vitamin).
In addition, analgesics that contain phenacetin
have been linked to kidney cancers, and a photochemotherapy regimen for psoriasis, which combines methoxysporalens with ultraviolet-A exposure, has been linked with skin cancer.
In chemical analysis, common undeclared pharmaceutical ingredients include ephedrine, chlorpheniramine, methyltestosterone, and phenacetin
. Heavy metals such as lead, arsenic, and mercury have been found in Asian medicines and herbal remedies from India (Borins, 1998; Keen et al., 1994; Ko, 1998; Markowitz et al., 1994).
N and P were determined by automated procedures, N by a micro-Kjeldahl method involving the formation of a blue indophenol compound, and P as the molybdenum blue complex; standards were made up with phenacetin
An example is a New Mexico case involving a man's regular use of Sinutab (containing phenacetin
) and its generic equivalent over an eight-year period.
Acetaminophen was first used in 1893; it gained widespread use in 1949, when it was proven to be less toxic than the then widely used phenacetin
A 20-year study of factory workers in Switzerland links chronic use of phenacetin
, a once-popular painkiller, to increased risks of high blood pressure, heart attacks and death from kidney disease, cancer and heart disease.