INBRIJA is not to be used by patients who take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine
or tranylcypromine within the last two weeks.
Clonidine potentiates the effects of tranylcypromine, phenelzine
and two analogues in the forced swimming test in mice.
The antidepressant phenelzine
protects neurons and astrocytes against formaldehyde-induced toxicity.
(23) Nutritional requirements for B-6 (pyridoxine or pyridoxal 5'-phosphate) may be increased by the use of certain medications (oral contraceptives, isoniazid, hydralazine, benserazide, penicillamine, phenelzine
, cycloserine, thiamphenicol carbidopa, etc.).
The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine
(Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).
Additionally, MAO inhibitors, such as clorgiline, phenelzine
, moclobemide and tranylcypromine, which are used to treat depression, and anticholinergics, such as scopolamine, biperidene, trihexyphenydil and benztropine, have some serious potential to increase mood and physical resistance, very similar to amphetamines.
- MAOIs: Tranylcypromine and phenelzine
have been involved in oral abuse due to their amphetamine-like structure; series of cases have been reported in particular with tranylcypromine.
Edema has been reported during treatment with various antidepressants such as mirtazapine, trazodone, tranylcypromine, phenelzine
and isocarboxazid (13-15).
Ryan, Administration of supplemental L-tyrosine with phenelzine
: A clinical literature review, Clinical Pharmacology Advances and Applications, 6, 107 (2014).
The principal antidepressant drugs are tricyclic antidepressants (e.g., clomipramine and imipramine), monoamine oxidase inhibitors (e.g., phenelzine
and selegiline), selective serotonin reuptake inhibitors (e.g., fluoxetine and fluvoxamine), selective dopamine reuptake inhibitors (e.g., amineptine and methylphenidate), selective norepinephrine reuptake inhibitors (e.g., reboxetine and viloxazine), and dual antidepressant drugs (e.g., venlafaxine and duloxetine) [4, 5].
"To date, the most common acrolein scavengers have been the FDA--[Food and Drug Administration] approved compounds containing a hydrazine group, such as hydralazine and phenelzine
," Shi says.