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A monoamine oxidase inhibitor, C8H12N2, used especially in the form of its sulfate as an antidepressant.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Noun1.phenelzine - monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression
MAOI, monoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
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References in periodicals archive ?
INBRIJA is not to be used by patients who take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine within the last two weeks.
Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice.
The antidepressant phenelzine protects neurons and astrocytes against formaldehyde-induced toxicity.
(23) Nutritional requirements for B-6 (pyridoxine or pyridoxal 5'-phosphate) may be increased by the use of certain medications (oral contraceptives, isoniazid, hydralazine, benserazide, penicillamine, phenelzine, cycloserine, thiamphenicol carbidopa, etc.).
The National Pregnancy Registry for Antidepressants (844-405-6185) is studying amitriptyline (Elavil), amoxapine (Asendin), bupropion (Forfivo XL and Wellbutrin), Citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), desvenlafaxine (Prisiq), doxepin (Sinequan), escitalopram (Lexapro), fluvoxamine (Luvox), fluoxetine (Prozac), imipramine (Tofranil), isocarboxazid (Marplan), levomilnacipran (Fetzima), maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), phenelzine (Nardill), protriptyline (Vivactil), selegiline (Emsam), sertraline (Zoloft), tranylcypromine (Parnate), trazodone (Desyrel), trimipramine (Surmontil), venlafaxine (Effexor), and vilazodone (Viibryd).
Additionally, MAO inhibitors, such as clorgiline, phenelzine, moclobemide and tranylcypromine, which are used to treat depression, and anticholinergics, such as scopolamine, biperidene, trihexyphenydil and benztropine, have some serious potential to increase mood and physical resistance, very similar to amphetamines.
- MAOIs: Tranylcypromine and phenelzine have been involved in oral abuse due to their amphetamine-like structure; series of cases have been reported in particular with tranylcypromine.
Edema has been reported during treatment with various antidepressants such as mirtazapine, trazodone, tranylcypromine, phenelzine and isocarboxazid (13-15).
Ryan, Administration of supplemental L-tyrosine with phenelzine: A clinical literature review, Clinical Pharmacology Advances and Applications, 6, 107 (2014).
The principal antidepressant drugs are tricyclic antidepressants (e.g., clomipramine and imipramine), monoamine oxidase inhibitors (e.g., phenelzine and selegiline), selective serotonin reuptake inhibitors (e.g., fluoxetine and fluvoxamine), selective dopamine reuptake inhibitors (e.g., amineptine and methylphenidate), selective norepinephrine reuptake inhibitors (e.g., reboxetine and viloxazine), and dual antidepressant drugs (e.g., venlafaxine and duloxetine) [4, 5].
"To date, the most common acrolein scavengers have been the FDA--[Food and Drug Administration] approved compounds containing a hydrazine group, such as hydralazine and phenelzine," Shi says.