phenformin


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Related to phenformin: paraldehyde

phenformin

(fɛnˈfɔːmɪn)
n
(Pharmacology) a biguanide administered orally in the treatment of diabetes to lower blood concentrations of glucose; it has been largely superseded by metformin. Formula: C10H15N5
[C20: from phen(yl) + form(aldehyde) +-in]
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Other oral biguanides, phenformin and buformin, were introduced in subsequent years.
Lack of effect of phenformin, pyridinolcarbamate combined with a decalcifying agent, and an onion-garlic mixture on growth and necrosis of aortic atherosclerosis in ballooned swine.
Phenformin had problems, though; it occasionally caused lactic acidosis and death and so was pulled off the US market in 1977.
McCarty MF: Homologous physiologicaleffects of phenformin and chromium picolinate.
While substances including phenformin and glibenclamide metabolite were detected in the patient's urine specimen, a sample of the product's remnants was also found to contain phenformin and glibenclamide upon testing by the Government Laboratory.
It has been demonstrated in vitro that stimulation of AMPK by metformin, phenformin, and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits ENaC conductance in Xenopus oocytes, HEK293 cells, and polarized renal epithelial cells [19,20].
Alessi, "Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR," American Journal of Physiology--Endocrinology and Metabolism, vol.
However, influenced by the side effects of phenformin, metformin was once suggested to exit the market.
One in 4,000 patients taking phenformin develops lactic acidosis (J.
It has been indicated that some specific hypoglycaemic medications such as glyburide, phenformin and tolazamide decrease endogenous content of CoQ10.
insulin, tolbutamide, phenformin, troglitazone, rosigitazone and repaglinide, are the mainstay of diabetes treatments and are effective in controlling hyperglycemia.
dagger]) One RCT of the 7 (N=204; 6% of total patients) used the biguanide phenformin rather than metformin.