The two co-primary endpoints of the EMERGE trial to be assessed at two hours after STS101 administration are freedom from pain and freedom from most bothersome symptom (photophobia, phonophobia
They reported that the decrease of pain severity and associated symptoms such as analgesic consumption, duration of headache and its frequency, nausea, vomiting, photophobia, phonophobia
, and limitations in functional activities were statistically significant in the treatment group, but not in the placebo group.
They averaged 4.6 migraine attacks per month, and their most bothersome symptoms included photophobia (57%), nausea (23.5%), and phonophobia
Rates of pain relief, and freedom from most bothersome symptom (MBS; patient selected from nausea, photophobia which is sensitivity to light, or phonophobia
, which is sensitivity to sound) were both higher and statistically significant starting as early as 30 minutes post-dose in the lasmiditan 100 mg and 200 mg treated groups (p<0.05) when compared with placebo.
In the general population TTH is the most frequent headache usually bilateral pressing of mild or moderate intensity and not associated with nausea or vomiting, no more than one of photophobia or phonophobia
. After mild head injury most frequently 85% seen pattern that resembles TTH.
The patient denied photophobia and phonophobia
. Her only medication was an oral contraceptive pill (OCP).
Assessment of otoacoustic emission suppression in women with migraine and phonophobia
. Neurol Sci 2016; 37: 703-9.
Migraine is a common neurovascular disorder with episodic attacks of throbbing headache, nausea /vomiting, photophobia, and phonophobia
. Migraine symptoms will lessen in up to 70% of pregnant women, usually during the second and third trimesters, but will worsen in 4%8%, and new-onset migraine may account for as many as 16% of all cases of the disorder in pregnancy.
Among cases of MWA, nausea was most common (n = 55) followed by vomiting (n = 44), photophobia (n = 23), and phonophobia
(n = 19).
Life time prevalence of Depressive disorder is 18 to 22% and one year rate is 2-5% having greater ratio in females than males.1 Migraine is a chronic neurological headache disorder accompanied with some autonomic nervous symptoms such as nausea, vomiting, photophobia (sensitivity to light) and phonophobia
(sensitivity to sound).
Other effects blamed by drivers include vertigo, phonophobia
, photophobia, back pain, loss of sensation, and headache accounting for 17.9% of cases.
The stitches are repeated irregularly, anywhere on the head, unilaterally or bilaterally; sometimes, it is associated with dizziness, vomiting, photophobia and phonophobia
, but without autonomic symptoms 2.