According to the company, KRN23 is an investigational recombinant fully human monoclonal IgG1 antibody, discovered by Kyowa Hakko Kirin, against the phosphaturic
hormone fibroblast growth factor 23 (FGF23).
A novel chromogenic in situ hybridization assay for FGF23 mRNA in phosphaturic
FGF23 is a novel bone-derived phosphaturic
factors involved in mineral metabolism disorder and increased with the decreased kidney function and phosphate accumulates.
mesenchymal tumour is a cause of tumour induced osteomalasia (TIO) which is a well-known para neoplastic association.
Tumor-induced osteomalacia is rare, but when it occurs is most commonly caused by benign phosphaturic
mesenchymal tumors among which hemangiopericytoma is the primary one (5).
6,7 Type II PHP is characterized by increased PTH, hypocalcemia, hyperphosphatemia and absolute lack of physical somatic features of AHO, further unique differentiating features is a normal cAMP response to PTH infusion but a deficient phosphaturic
response indicating a defect distal to c AMP generation in renal cells and normal GNAS1 activity.
effect of dopamine in dogs: possible role of intrarenally produced dopamine in phosphate regulation.
These and other disorders leading to HRO such as fibrous dysplasia (FD) are associated with increased secretion of phosphaturic
substances called 'phosphatonins' which cause proximal tubular leak of phosphate resulting in hypophosphataemia.