phosphodiester bond


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phos·pho·di·es·ter bond

 (fŏs′fō-dī-ĕs′tər)
n.
A covalent chemical bond that links two carbon atoms through a phosphate group, especially the bonds that link the pentose sugars of adjacent nucleotides in polynucleotide chains of RNA and DNA.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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These enzymes catalyze the reaction of nucleic acid phosphodiester bond hydrolysis at the 5 'end of the oxidized nitrogen base, while the 3'-hydroxyl and 5'-phosphate ends remain free.
If the padlock probe is mixed with target nucleic acids containing these sequence complements, thermally denatured and reannealed, it can hybridize down to its target at both ends, effectively circularizing the probe and placing its 3' and 5' ends immediately next to each other, but with a nick--that is, missing the phosphodiester bond; see Figure lb.
Thus, the position of [Mg.sup.2+] being a solid ion strongly depends on the tight coupling of P-O, while [Mn.sup.2+] is closer to the N7 position of guanine, wherein the interaction with the oxygen of the previous phosphodiester bond is maintained [31].

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