Also found in: Medical, Wikipedia.
Related to phosphodiesterase: Phosphodiesterase inhibitors


 (fŏs′fō-dī-ĕs′tə-rās′, -rāz′)
Any of a class of enzymes that catalyze the hydrolytic cleavage of phosphodiester bonds and are important in breaking down cyclic AMP, cyclic GMP, and nucleic acids.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Mentioned in ?
References in periodicals archive ?
In the study, the researchers looked at resveratrol's effect on phosphodiesterase 4 (PDE4), an enzyme influenced by the stress hormone corticosterone, in mice.
Resveratrol is a non-flavonoid polyphenol compound, naturally present on the skin and inside the seeds of grapes as well as berries, offering various health benefits.A TheA ( recent study titled, "The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition," was published in Neuropharmacology on July 15 and shed some light on the relationship between wine and stress hormone corticosterone's enzyme called phosphodiesterase 4 (PDE4).A
M2 PRESSWIRE-July 29, 2019-: Global Phosphodiesterase (PDE) Inhibitors Market Research Report 2019-2023: Key Players are Bayer, Eli Lilly & Co, GlaxoSmithKline, Pfizer, and Vivus
The product is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4), particularly for cyclic adenosine monophosphate.
Scientists also found that by decreasing the release of a specific enzyme, called phosphodiesterase, symptoms of obesitylinked depression can be reduced.
The effects of phosphodiesterase type 5 inhibitors on penile rigidity variables during a period with no sexual stimulation: A laboratory setting double-blind study.
Food and Drug Administration last year placed Viagra (sildenafil) and other ED drugs known as phosphodiesterase type 5 (PDE5) inhibitors on its watch list of medications with possible safety issues.
PTP1B belongs to the protein-tyrosine-phosphatase family, and the similar enzymes are Phosphodiesterase 4D ( and Phosphodiesterase 5A (
Tadalafil tablets are a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), and both ED and the signs and symptoms of BPH.
The company uses structure-guided drug design to discover mechanistically novel, allosteric inhibitors of phosphodiesterase 4, an enzyme family that plays key roles in memory formation, learning, neuroinflammation, and traumatic brain injury.
We conducted a prospective study of transient evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) in men who were taking an oral phosphodiesterase type 5 (PDE5) inhibitor for erectile dysfunction.
Crisaborole (Eucrisa) is a phosphodiesterase 4 (PDE-4) inhibitor, a new type of chemical entity "based on a different pathway of decreasing inflammation," said Dr.

Full browser ?