phosphorylate

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phos·pho·ryl·ate

 (fŏs′fər-ə-lāt′)
tr.v. phos·pho·ryl·at·ed, phos·pho·ryl·at·ing, phos·pho·ryl·ates
To add a phosphate group to (an organic molecule).

phos′pho·ryl·a′tion n.
phos′pho·ryl·a′tive adj.

phosphorylate

(fɒsˈfɒrɪˌleɪt)
vb (tr)
(Chemistry) chem to cause or go through phosphorylation

phos•pho•ryl•ate

(ˈfɒs fər əˌleɪt, fɒsˈfɔr ə-, -ˈfɒr-)

v.t. -at•ed, -at•ing.
to introduce the trivalent group =P=O into an organic compound.
phos`pho•ryl•a′tion, n.
References in periodicals archive ?
More years of play correlated with more severe white matter rarefaction and greater phosphorylated tau accumulation in a simultaneous equations regression model controlling for age and race.
KEYWORDS: Phosphorylated AMPK, p-AMPK, Immunohistochemistry, Colorectal cancer.
In this context, we have shown that phosphorylated CAR is also important for maintaining junctions between proliferating human lung cancer cells and this in turn promotes optimal signaling downstream of epidermal growth factor receptor (EGFR) to perpetuate cell division.
Measurement of the expression of the proteins: The immunoreactivity of Akt (total and phosphorylated) and GSK3 (total and phosphorylated) was studied in the isolated hippocampus using an ELISA commercial kit (MyBioSource, San Diego, USA) according to previous studies.
These proteins can attch to phosphorylated receptors, Jaks or STAT proteins to deactivate signaling molecules.
In addition, Matrin-3 was highly expressed and phosphorylated in regions of the fetal mouse brain where there is an abundance of neural stem cells.
Additional research presented compared levels of phosphorylated neurofilament heavy chain in plasma in more than 300 patients from Spinraza clinical trials, including those in the NURTURE study, and a control group of people without SMA.
Primary antibodies used included Epac1, IL-1[beta], Rap 1 (Abcam, Cambridge, MA), phosphorylated p38 MAPK, total p38 MAPK, phosphorylated JNK, total JNK, phosphorylated insulin receptor (Tyr 1150/1151), total insulin receptor, phosphorylated Akt (Ser473), total Akt, Akt2, phosphorylated IRS-1 (Ser307), total IRS-1 (Cell Signaling Corp, Danvers, MA), and beta-actin (Santa Cruz, CA).
Total phosphorylated cellular proteins were extracted with 1x cell lysis buffer containing protease inhibitors and two phosphatase inhibitors (Raybiotech, USA).
Rabbit polyclonal antibodies against phosphorylated p38 MAPKs and total p38 MAPKs and rabbit monoclonal antibodies against phosphorylated c-Jun and total c-Jun were purchased from Cell Signaling Technology (Danvers, MA).
With the addition of the catalyst imidazole, a simple organic compound that was itself plausibly present on the early Earth, DAP's activity also led to the appearance of short, RNA-like chains of these phosphorylated building blocks.

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