Subsequent biochemical analyses found that Erk5 directly phosphorylates
Smad1 at Ser206 in the linker region, which is known to trigger its proteasomal degradation in a Smad-specific E3 ubiquitin ligase 1 (Smurf1)-dependent manner.
PLK1 uniquely phosphorylates
translational control tumor protein to form pTCTP and inhibition of this enzymatic activity by Onvansertib appears to be predictive of patient response to treatment.
via the same phosphorus-nitrogen bond breakage and under the same conditions as protein kinases, which are ubiquitous in present-day life forms," he said.
Woods et al., "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates
AMP-activated protein kinase," The Journal of Biological Chemistry, vol.
Nakamura, "Activated Fyn phosphorylates
[alpha]-synuclein at tyrosine residue 125," Biochemical and Biophysical Research Communications, vol.
Activated FAK/Src complex phosphorylates
cytoskeletal adaptor paxillin which promotes cell migration .
PDK1, a protein kinase that phosphorylates
and thus inactivates pyruvate dehydrogenase alpha subunit, was more than 2-fold over expressed in frataxin knockdown cells.
Additionally, MLK-1 was found to be tyrosine-phosphorylated in the presence of the wild-type, but not a kinase-dead mutant form of SVH-2, suggesting that SVH-2 directly phosphorylates
The phosphorylation state of MLC depends on the balance between MLCK, which phosphorylates
MLC leading to smooth muscle cell contraction, and MLCP, which dephosphorylates MLC, resulting in smooth muscle cell relaxation.
Protein tyrosine phosphatase 1B (PTP1B) has been implicated in the negative regulation of the signaling pathway that phosphorylates
the tyrosine residue.
Upon activation by growth factors, PI3K phosphorylates
the D3 position of phosphatidylinositols producing the second messenger PtdIns(3,4,5)P3 that binds to the pleckstrin homology (PH) domain of AKT and translocates this kinase to the plasma membrane where it gets activated by upstream kinases .
I-[kappa]B and IKK[alpha] phosphorylates
the NF-[kappa]B2/p100 precursor (12).