is the scientific name for UV-generated DNA damage.
"The US is a large market and very important to Asahi," said Aki Kato, managing director at Asahi Photoproduct
, in announcing the agreement.
It can render DNA non-amplifiable through the formation of cyclobutane pyrimidine dimers and, to a lesser extent, what's known as the "6-4 photoproduct
"; in either case, it's the creation of covalent bonds between adjacent bases on a DNA strand that disrupts their ability to hydrogenbond as needed to serve as a replication template.
Thermal reopening of the diaziridine cycle in dark conditions after the end of irradiation is clearly observed only for 1 (Figure 2(b)); the lifetime of the photoproduct
1 C was calculated as [tau] = 1538 s.
A similar photochemical method for the assay of riboflavin (RF) on the basis of the formation of its photoproduct
, lumichrome (LC) and LC: RF ratio, has been reported .
It has been suggested that photosensitizing dyes used in chromovitrectomy could enhance phototoxicity by increasing levels of free radicals, creating a photoproduct
that could be harmful to retinal cells.
The resulting photoproduct
creates a lesion that distorts the DNA helix, creating adducts that can stop the transcription and replication .
These oscillations seem to emanate from coherence at the vibrational ground states of the photoproduct
Grogan, "Sulfolobus mutants, generated via PCR products, which lack putative enzymes of UV photoproduct
repair," Archaea, vol.
The new photoproduct
is excited with another "read" laser and the corresponding fluorescence is captured at two instants of time (undelayed and delayed).
Nairn, "The biology of the (6-4) photoproduct
," Photochemistry and Photobiology, vol.