And importantly, the cells performed a crucial function of mature RPE cells: they engulfed the tips of photoreceptor
outer segments, a pruning process that keeps photoreceptors
Further studies in a mouse model of ciliopathy confirmed an important temporal relationship: Looking across several early development stages, the RPE defects preceded the photoreceptor
degeneration, which provides additional insights into ciliopathy-induced retinal degeneration.
Scientists at the University of Queensland in Australia have discovered a new type of cell that displays properties of both rod and cone photoreceptor
Most cases of incurable blindness occur due to the loss of millions of light-sensitive photoreceptor
cells that function like camera sensors.
Lead researcher Dr Roly Megaw said that by furthering the understanding of the RPGR gene and its effects on photoreceptor
cells, they hope that these findings bring them closer to developing a possible treatment for this devastating disease.
1956), and circadian rhythms in regulating retinal and photoreceptor
responsiveness and sensitivity to light (Barlow etal.
In RP, which affects approximately 100,000 Americans and 1 in 4,000 persons worldwide, rod-specific genetic mutations cause rod photoreceptor
cells to dysfunction and degenerate over time.
Most people know at least a little about the retina, a thin tissue an inch in diameter that contains all the photoreceptor
cells responsible for beginning vision and their circuits that produce signals that become vision.
They enhance vision by absorbing scattered light and delivering nutrients to photoreceptor
1,2) Foveal thinning and disruptions of the photoreceptor
inner and outer segment (IS/OS) junction are observed on spectral domain optical coherence tomography (SD-OCT).
The product will be delivered to patients upon diagnosis and is aimed at blocking photoreceptor
cells from dying until surgery can be completed.
Excessive light exposure leads to photoreceptor
degeneration and several studies have suggested that a long-term history of exposure to light may have some impact on the incidence of age-related macular degeneration.