The nano-enabled hybrid technology's relevance derives from an ability to enhance potency through targeted delivery of photosensitizer
in combination with reactive oxygen, and carry an imaging agent to confirm patient specific dose and site-specific impact for minimized side effects.
application of a photosensitizer
such as psoralen and aminolevulinic acid.
Opresko and her team are now beginning to further explore the consequences of oxidative stress on telomeres using a novel photosensitizer
, developed by Marcel Bruchez at Carnegie Mellon University that produces oxidative damage selectively in telomeres.
monitor the kinetic reaction of photosensitizer
and adapt the irradiance according to the patient~s response.
Hydrochlorothiazide, a known photosensitizer
, when taken by white non-Hispanic patients with a history of multiple SCC, skin cancers may represent a 'correctable' cause.
The delivery of PDT to the entire surgical field is essential, thus selective photosensitizer
accumulation in diseased cells is necessary to avoid therapy-limiting damage to normal tissues.
Singlet oxygen, a reactive form of oxygen, is generated by energy transfer from a photosensitizer
to molecular oxygen [O.
Ground state oxygen can directly absorb visible light of 765 nm, even in mammalian cells, leading to formation of singlet oxygen without the involvement of a photosensitizer
Abstract: In recent years, photodynamic therapy (PDT) using a combination of photosensitizer
and laser light source has been used in periodontal therapy.
Polygrama, together with Acrilar, produces the resins, monomers and photosensitizer
, with Muller testing the material and refining the chemistry, especially the photo-initiator.
Methylene blue (MB) is a well-established photosensitizer
that has been used in PDT for targeting various gram-positive and gram-negative oral bacteria and was previously used to study the effect of PDT on endodontic disinfection.
10) The selective uptake and retention of the photosensitizer
in tumor cells allows for targeted treatment.