We have built a unique R&D technology platform to expand our understanding of the physiopathology
and etiology of inner ear related diseases enabling us to select the best targets and modalities for drug candidates.
The Genetics and Physiology of the Hearing Unit of Institut Pasteur, led by Professor Christine Petit, has developed world-class expertise in the molecular physiology and physiopathology
of the hearing system.
is unknown, suggesting the participation of immunocomplexes and T lymphocytes with cross-reactivity against synovial antigens (1).
Although the exact etiology is not clearly known, the factors affecting the physiopathology
of anal fissure are thought to include disadvantageous anatomic structure such as tight anal sphincter and multifactorial origin, such as internal anal sphincter spasms, ischemia, infectious conditions, and local traumas due to hard stool passage, long-lasting constipation, or diarrhea.
Furthermore, we should remember that BD has a high comorbidity with metabolic syndrome, which may also contribute toward microangiopathy and vascular dementia scenarios, whose physiopathology
is different from dementia due to neurodegeneration.
Many disorders seen in patients without an effective treatment have encouraged basic researchers to look for novel approaches in the use of animal models of cognitive impairment, which is important for the understanding of its physiopathology
and also the development of new therapies (Gornicka-Pawlak et al., 2015; Dalrymple-Alford et al., 2015; Huijgen and Samson, 2015; Danet et al., 2015).
Behcet's disease physiopathology
: a contemporary review.
However, due to ethics and standardization problems in clinical studies, experimental studies have been mostly preferred for physiopathology
and healing procedures (3-9).
There are many opinions about the physiopathology
of urinoma, most of which are chronic ureteral obstruction resulting in pyelosinus back-flow, renal sinus extravasation with pyelolymphatic and pyelovenous back-flow by 35-40 cm [H.sub.2]O and/or more increase in intrapelvic pressure, and therefore the resultant perirenal extravasation (14).
Consequently the disorder is deemed immune mediated due to excellent response to the steroid therapy despite the unclear physiopathology
. Different regimens of corticosteroid treatment have been used in various studies.
(8,9) The hypothesis that microperforations in the ILM may be responsible for the physiopathology
is supported by findings of retinal pigment epithelium (RPE) cells and retinal glial cells in postoperative histopathologic ERM examination in patients with no history of trauma, laser photocoagulation, or crypexy and no previous clinical findings of retinal pathology such as tear or hole.