Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.


 (fī′sō-stĭg′mēn′) also phy·so·stig·min (-mĭn)
A crystalline alkaloid, C15H21N3O2, extracted from the Calabar bean, used in the form of its sulfate as a miotic and in the form of its salicylate as a cholinergic agent. Also called eserine.

[New Latin Phȳsostigma, genus name of the Calabar bean (Greek phūsa, bladder, from the appendage at the end of the stigma that was formerly thought to be hollow + stigma) + -ine.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌfaɪsəʊˈstɪɡmiːn) or


(Elements & Compounds) an alkaloid found in the Calabar bean used esp in eye drops to reduce pressure inside the eyeball. Formula: C15H21N3O2. Also called: eserine
[C19: from New Latin Physostigma genus name, from Greek phusa bladder +stigma mark]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌfaɪ soʊˈstɪg min, -mɪn)

an alkaloid, C15H21N3O2, used in the treatment of Alzheimer's disease to raise the level of the neurotransmitter acetylcholine.
[1860–65; < New Latin Physostigm(a) genus of plants yielding the alkaloid (< Greek phŷs(a) bladder, bellows + New Latin -o- -o- + stigma stigma) + -ine2]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.physostigmine - used in treatment of Alzheimer's disease and glaucoma
medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease
alkaloid - natural bases containing nitrogen found in plants
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n fisostigmina
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Physostigmine is known to prolong neurotransmitters, dilate blood vessels and slow the heartbeat.
cytisine, nicotine and its metabolite cotinine, physostigmine, and
From the compounds assigned in vivo to the acute oral toxicity category 1 (fatal if swallowed), three (i.e., brucine, disulfoton, and physostigmine) target the nervous system and act via specific mechanisms (e.g., inhibition of cholinesterase, antagonism of glycine receptor).
For cholinesterase inactivation, physostigmine salicylate (eserine) was added to serum samples prior to the assay.
The ginseng was given at three different doses: 10, 50, and 100 mg/kg Soares et al., icv injection of 20.3 Fatiguing, constant- 2003 (13); 2004 [micro]M of L-TRP, a speed treadmill (30); 2007 (29) precursor for 5-HT running at 18 m-min synthesis, (5% grade) at 23 [+ immediately before or -] 2[degrees]C the exercise Rodrigues et al., icv injection of 5 x Fatiguing, constant- 2009 (16) [10.sup.-3] M of speed treadmill physostigmine, a drug running at 20 m-min that blocks the (5% grade) at 23 [+ running-induced or -] 2[degrees]C increase in 5-HT in the preoptic area, immediately before the exercise Leite et al., icv injection of 60 Fatiguing, constant- 2010 (32) nmol of losartan speed treadmill immediately before running at 18 m-min the exercise.
Physostigmine therapy is recommended in severe clinical states such as malignant dysrhythmias, coma, respiratory failure requiring mechanical ventilation, and uncontrolled hyperthermia.
Thomas, "Interactive effects of light/dark cycle, ECS, physostigmine, and scopolamine on one-way avoidance learning in rats," Physiological Psychology, vol.
Eadie, "The inhibition of cholinesterase by physostigmine and prostigmine," The Journal of Biological Chemistry, vol.