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 (fī′sō-stĭg′mēn′) also phy·so·stig·min (-mĭn)
A crystalline alkaloid, C15H21N3O2, extracted from the Calabar bean, used in the form of its sulfate as a miotic and in the form of its salicylate as a cholinergic agent. Also called eserine.

[New Latin Phȳsostigma, genus name of the Calabar bean (Greek phūsa, bladder, from the appendage at the end of the stigma that was formerly thought to be hollow + stigma) + -ine.]


(ˌfaɪsəʊˈstɪɡmiːn) or


(Elements & Compounds) an alkaloid found in the Calabar bean used esp in eye drops to reduce pressure inside the eyeball. Formula: C15H21N3O2. Also called: eserine
[C19: from New Latin Physostigma genus name, from Greek phusa bladder +stigma mark]


(ˌfaɪ soʊˈstɪg min, -mɪn)

an alkaloid, C15H21N3O2, used in the treatment of Alzheimer's disease to raise the level of the neurotransmitter acetylcholine.
[1860–65; < New Latin Physostigm(a) genus of plants yielding the alkaloid (< Greek phŷs(a) bladder, bellows + New Latin -o- -o- + stigma stigma) + -ine2]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.physostigmine - used in treatment of Alzheimer's disease and glaucoma
medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease
alkaloid - natural bases containing nitrogen found in plants


n fisostigmina
References in periodicals archive ?
3] M of speed treadmill physostigmine, a drug running at 20 m-min that blocks the (5% grade) at 23 [+ running-induced or -] 2[degrees]C increase in 5-HT in the preoptic area, immediately before the exercise Leite et al.
Physostigmine therapy is recommended in severe clinical states such as malignant dysrhythmias, coma, respiratory failure requiring mechanical ventilation, and uncontrolled hyperthermia.
Physostigmine is the specific antidote, which can be given in serious cases.
A comparison of various forms of physostigmine administration.
Physostigmine, Ellman's reagent (DTNB, 5,5'-dithiobis(2-nitrobenzoic acid)), ATCh (acetylthiocholine iodide), BTCh (S-butyrylthiocholine iodide), AChE (acetylcholinesterase, Electrophorus electricus), BuChE (human plasmabutyrylcholinesterase), sodium phosphate buffer, pH 7.
The Novascreen acetylcholinesterase (AChE) analysis in ToxCast[TM] consists of an in vitro cell-free biochemical assay that detects the inhibition of human-derived AChE enzyme, as determined colorimetrically by enzyme reporter activity using the substrate acetylcholine and a positive control of physostigmine (U.
2,4,5) In table 1 gastric lavage and physostigmine are both listed as being recommended for treatment in the setting of D.
2007) Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats.
The cholinergic agent physostigmine is capable of reversing the central nervous system effects of anticholinergics, such as scopolamine and tricyclic antidepressants.