(Sigma-Aldrich), a blocker of the [GABA.
E, F) Effects of a GABA antagonist, picrotoxin
, (PTX, 100[micro]M).
In a study, (S)-(+)-carvone (200 mg/kg) was reported to increase the latency of convulsions induced by PTZ and picrotoxin
There are no credible evidence of anticonvulsant effect of this plant in bibliographic resources and databases, so methanolic extracts of papaver somniferum on generalized tonic seizures and clonic seizures induced by picrotoxin
in mice has been studied.
Effect of intra cerebro ventricular picrotoxin
and muscimol on intravenous bupivacaine toxicity.
Epileptiform activity recordings: Artificial cerebro spinal fluid (ASCF) containing the GABAa receptor blocker picrotoxin
(100 [micro]M) was bath applied and the same was used in electrodes.
GluCls are activated by the glutamate analog, ibotenic acid, and are inhibited weakly by the ligand-gated chloride channel blocker, picrotoxin
(Smith et al.
2010) screened for RDX binding to different neurological receptors and found that RDX binds to the picrotoxin
binding site in the chloride channel of the [gamma]-aminobutyric acid A (GABAA) receptor, an interaction associated with the onset of seizures in rats.
The goal of this project is to determine if picrotoxin
has an effect in the supraesophageal ganglion (the location of the secondary and tertiary auditory interneurons) of female Acheta domesticus.
The first group was designated as control group; and the second as the picrotoxin
(10mg/kg; intraperitoneal) alone group.
Administration of the GABA antagonist picrotoxin
after extinction training enhanced prolonged extinction.
apigenin significantly shortened the latency period of picrotoxin
induced fits but did not reduce the incidence of seizures.