Though EMA was "a great regulatory body" and the GMP review an important initiative overall, piperacillin
shortages should be avoided because second-choice drugs would put patients' lives at risk from avoidable infections, he argued.
The study developed statistical methods to predict phenotypic resistance from resistance genes for various combinations of the four bacterial species and the antibiotics gentamicin, tobramycin, ciprofloxacin, levofloxacin, trimethoprim-sulfamethoxazole, ertapenem, imipenem, cefazolin, cefepime, cefotaxime, ceftazidime, ceftriaxone, ampicillin, piperacillin
Here, is a case of SJS-type reaction secondary to piperacillin
in surgical ICU at AFIC/NIHD.
coli isolates, the sensitivity pattern towards, Cefepime Tazobactam was 90%, Cefepime--32%, Piperacillin
Tazobactam -75%, Cefoperazone sulbactam 71%, Carbapenem- 91%, and Amikacin- 92%.
(20) The following antimicrobial agents were examined: amikacin (30 [micro]g), aztreonam (30 [micro]g), cefepime (30 [micro]g), cefotaxime (30 [micro]g), ceftazidime (30 [micro]g), cefuroxime (30 [micro]g), ciprofloxacin (5 [micro]g), colistin (10 [micro]g), gentamicin (10 [micro]g), imipenem (10 [micro]g), meropenem (10 [micro]g), piperacillin
(100 [micro]g), piperacillin/tazobactam (110 [micro]g), tobramycin (10 [micro]g), and trimethoprim/sulfamethoxazole (23.75 [micro]g/1.25 [micro]g).
Piperacillin-tazobactam (PTZ) is a combination of piperacillin
and the blactamase inhibitor tazobactam.
parvulum Penicillin S Ampicillin S Amoxicillin/clavulanate S Piperacillin
S Piperacillin/tazobactam S Metronidazole S Imipenem S Meropenem S Clindamicyn S Vancomycin S
Pseudomonas aeruginosa Correlation p value Correlation p coefficient (r) coefficient (r) value Total antibiotics -0.393 0.383 -0.252 0.585 Piperacillin
0.739 0.058 -0.345 0.448 /tazobactam Ampicillin -0.571 0.180 -0.162 0.728 /sulbactam Third generation 0.643 0.119 0.198 0.670 of cephalosporins Carbapenems 0.500 0.253 0.126 0.788 Tigecycline 0.821 0.023 -0.018 0.969 Aminoglycosides -0.857 0.014 0.054 0.908 Fluoroquinolones 0.429 0.337 -0.162 0.728 Colistin 0.643 0.119 0.270 0.558 TABLE 3.
pneumoniae Kp81 Amikacin [greater than or equal to] 64 (R) Aztreonam [greater than or equal to] 64 (R) Cefepime [greater than or equal to] 64 (R) Ceftazidime [greater than or equal to] 64 (R) Ciprofloxacin [greater than or equal to] 4 (R) Colistin [less than or equal to] 0.5 (S) Gentamicin [greater than or equal to] 16 (R) Imipenem [greater than or equal to] 16 (R) Meropenem [greater than or equal to] 16 (R) Piperacillin
[greater than or equal to] 128 (R) Piperacillin/tazobactam [greater than or equal to] 128 (R) Ticarcillin [greater than or equal to] 128 (R) Ticarcillin/clavulanic acid [greater than or equal to] 128 (R) Tigecycline 1.5 (S) Tobramycin [greater than or equal to] 16 (R) Trimethoprim/sulfamethoxazole [greater than or equal to] 320 (R) Drug MIC, mg/L (susceptibility) E.
In a pilot study, piperacillin
(87 mg/kg) in combination with tazobactam (11 mg/kg) was administered intramuscularly (IM) to 2 birds, and blood samples were obtained at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, and 10 hours after administration.
cefixime, ceftazidime, co-trimoxazole, ciprofloxacin, gentamicin, amikacin, cefoperazone + sulbactam, piperacillin
+ tazobactam, meropenem, polymyxin - B, and aztreonam were used.