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a. A highly infectious epidemic disease, especially one with a high rate of fatality; a pestilence.
b. A virulent, infectious disease that is caused by the bacterium Yersinia pestis (syn. Pasteurella pestis) and is transmitted primarily by the bite of fleas from an infected rodent, especially a rat. In humans it occurs in bubonic form, marked by lymph node enlargement, and in pneumonic form, marked by infection of the lungs, and can progress to septicemia.
a. A widespread affliction or calamity seen as divine retribution.
b. An influx or large number of destructive or unwanted things, especially animals: "The vines flourished, the only problem being a plague of jackrabbits" (Paul Lukacs).
c. Something that causes persistent hardship, trouble, or annoyance: "The plague of every funnyman's success is that deep down, almost everyone thinks they know forty guys funnier" (Ross Vachon).
tr.v. plagued, plagu·ing, plagues
1. To pester or annoy persistently or incessantly. See Synonyms at harass.
a. To cause suffering or hardship for: "Runaway inflation further plagued the wage- or salary-earner" (Edwin O. Reischauer).
b. To be a widespread or continuous problem or defect in: Confusing jargon plagues the entire subject.

[Middle English plage, blow, calamity, plague, from Late Latin plāga, from Latin, blow, wound; see plāk-2 in the Appendix of Indo-European roots. V., Middle English plaghen, from Middle Dutch, from plaghe, plague, from Late Latin plāga.]

plagu′er n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Ordoyo, Solcom chief, said troopers encountered the merged groups of the Sangay sa Platoon (SPN), codenamed "Plaguer" and the Yam-Ay Guerrilla Front of the NPA's Southern Tagalog Regional Party Committee (STRPC), codenamed "Caloy." After a 10-minute encounter, the rebels retreated and left behind an assortment of rebel effects of intelligence value.