The effect of B-cell depletion therapy on serological evidence of B-cell and plasmablast
activation in patients with rheumatoid arthritis over multiple cycles of rituximab treatment.
(18) These histologic findings, in addition to the presence of a tumefactive lesion, involvement of multiple classic organs (synchronously or metachronously), subacute onset, elevated serum IgG4, elevated plasmablast
levels, and swift response to immunosuppressive therapy, strongly favor the diagnosis of IgG4-related disease.
Autophagy is activated in systemic lupus erythematosus and required for plasmablast
BMSCs can suppress B cell proliferation, differentiation toward plasmablast
, and immunoglobulin production dependent on galectin-9 or IL-1Ra signaling [51, 52].
Yamaoka et al., "Number of circulating follicular helper 2 T cells correlates with IgG4 and interleukin-4 levels and plasmablast
numbers in IgG4-related disease," Arthritis & Rhematology, vol.
Grywalska et al., "Antibody and plasmablast
response to 13-valent pneumococcal conjugate vaccine in chronic lymphocytic leukemia patients--preliminary report," PLoS One, vol.
expansion is oligoclonal, not polyclonal," Dr.
CD staining was performed which demonstrated a background of T-cells with occasional microscopic foci of lambda restricted plasmablast
(HHV-8+), variably expressing CD20 seen invading follicles.
Tumor proliferation was composed of large cells with plasmablast
's or immunoblast's morphology, disposed in small clusters, large sheets, or nodules [1-7].
Leahy et al., "Dual-reactive B cells are autoreactive and highly enriched in the plasmablast
and memory B cell subsets of autoimmune mice," Journal of Experimental Medicine, vol.
Plasma cell population predominantly comprised of plasmablast
, intermediate plasma cells and few mature forms.
For the plasmacytic cell series they recommended the terms "plasmablast
," "proplasmacyte" and "plasmacyte" identify these cells, and they proposed that the term "plasma cell" be avoided; however, both terms, plasmacyte and plasma cell, are still used interchangeably.