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 (plī-ŏt′rə-pē) also plei·ot·ro·pism (-pĭz′əm)
n. Biology
The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated phenotypic effects.

[Greek pleiōn, more; see pelə- in Indo-European roots + -tropism.]

plei′o·tro′pic (plī′ə-trō′pĭk, -trŏp′ĭk) adj.


(plaɪˈɒ trə pi)

the phenomenon of one gene affecting more than one phenotypic characteristic.
plei`o•trop′ic (-əˈtrɒp ɪk, -ˈtroʊ pɪk) adj.
plei`o•trop′i•cal•ly, adv.
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References in periodicals archive ?
Due to its pleiotropic effects, nifuratel can be used for all kinds of vaginitis caused by bacteria, trichomonas and molds infection.
Objective: The aim of this grant is to understand how mammalian developmental genes, which are usually pleiotropic, are controlled via long-range regulations and how chromatin partitions into large and discrete regulatory domains, generally matching Topologically Associating Domains (TADs).
Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia.
IL-4, a multifunctional pleiotropic cytokine discovered in the mid-1980s, remains a focus of attention and continues to spur vigorous research efforts.
This appears to be because of pleiotropic effects linking metabolism and plumage color (Ducrest et al.
The potentially pleiotropic effects of vitamin D analogues support the hypothesis that vitamin D deficiency is a universal risk factor.
Pleiotropic action of renal cell carcinoma-dysregulated miRNAs on hypoxia-related signaling pathways.
During the past decade statins also have been demonstrated to have multiple pleiotropic primary and secondary cardiovascular protective effects, even in those with normal or low blood cholesterol levels.
Interleukin-10 (IL-10) is a potent pleiotropic cytokine, located on chromosome 1q31-32, consisting of five exons and four introns.
Other explanations offered include the suppression of coenzyme Q10 production, as well as the pleiotropic effects of statins.
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of antimalarial drug precursor, artemisinic acid.