Also found in: Medical, Encyclopedia, Wikipedia.


 (plī-ŏt′rə-pē) also plei·ot·ro·pism (-pĭz′əm)
n. Biology
The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated phenotypic effects.

[Greek pleiōn, more; see pelə- in Indo-European roots + -tropism.]

plei′o·tro′pic (plī′ə-trō′pĭk, -trŏp′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(plaɪˈɒtrəˌpɪzəm) or


(Genetics) genetics the condition of a gene affecting more than one characteristic of the phenotype
pleiotropic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Nemet, "Heterogeneity and pleiotropism in the Moebius syndrome," Clinical Genetics, vol.
The abovementioned protective effects promoted by Cr are likely to depend on multiple mechanisms, a notion in line with the well-established Cr pleiotropism [3,12, 50-52].
However, the reasons for the pleiotropism and variability of SLC29A3 -related diseases are not known.
Pleiotropism: The term refers to the phenomenon in which a single gene is responsible for a number of distinct and seemingly unrelated phenotypic effects.
Common features shared by all CKs are pleiotropism, promiscuity, and redundancy, with a single CK able to bind several receptors, whereas multiple CKs bind the same receptor resulting in the same functional outcome 27].
These effects have to be checked in these mutants from the beginning and their performance must be evaluated, as ever since the economical value of a desirable mutant may finally depend on favorable or unfavorable characters connected with the mutant by linkage or pleiotropism.