Blood smear shows hypochromia, microcytosis, marked anisocytosis, fragmented and nucleated red cells, polychromasia
and occasionally immature leukocytes.
The bird had a mild regenerative anemia (packed cell volume [PCV] 34%; 48% [+ or -] 5%; range, 39%-55%), characterized by polychromasia
and anisocytosis and a mild hypoproteinemia (3.2 g/dL; 6.3 [+ or -] 1.7 g/dL; range, 4.4-10.5 g/dL).
A known myelotoxic agent, benzene affects erythrocytes, leukocytes and platelets, respectively causing anemia, polychromasia
, basophilic stippling and peripheral erythroblasts, lymphopenia and thrombocytopenia (28).
The PBS showed moderate polychromasia
and numerous red cell fragments, as well as occasional spherocytes (Fig.
Seven months later, the patient returned to the hospital with lassitude, paleness and weakness, and analyses revealed that hemoglobin: 4.7 g/dL, widespread schistocytes, spherocytes, polychromasia
. Direct Coombs was 4+ positive and total bilirubin was 5.4 mg/dL, direct bilirubin was 1.2 mg/dL, C3, C4, antinuclearantibody, anti-dsDNAand immunoglobulin levels were normal.
Laboratory testing was significant for white blood cell count of 53.3 G/L, and differential included 88% neutrophils, 4.5% lymphocytes, 3.3 G/L monocytes, 0.15 G/L basophils, 3+ poikilocytosis, 2+ polychromasia
, 1+ Howell-Jolly bodies, and 1+ vacuolated polymorphonuclear lymphocytes with target and sickle cells present.
The peripheral blood smear showed moderate schistocytosis and moderate polychromasia
, in keeping with haemolysis (Table 1).
was found in 15% of patients, and target cell was detected in 12% of patients.
Peripheral smear showed moderate red cell anisopoikilocytosis and polychromasia
. Neutrophils, lymphocytes, and platelets were morphologically normal.
PBF showed polychromasia
with a marked leucoerythroblastic picture.
Investigations revealed a hemoglobin =9.2g/dl, White cell count =5000/cmm (neutrophils=20%, lymphocytes=70%, monocytes=08%, eosinophils=02%), platelet count = 206,000/cmm, hematocrit =30.2, mean corpuscular volume =87.3fL, anisocytosis, polychromasia
and a reticulocyte count =2%.
on PBF is synonymous with reticulocytosis.