A 65-year-old female was referred to haematology clinic for progressive polycythaemia
. She had a past history of hypertension, chronic kidney disease, organic bipolar disorder, and irritable bowel syndrome.
Patients with JAK2 negative polycythaemia
were tested for the cause of polycythemia.
The effect of testosterone on erythropoiesis is dose-dependent and polycythaemia
in response to overreplacement with testosterone is well-known .
Le Couedic et al., "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia
vera," Nature, vol.
In patients with cyanotic heart disease, underlying coagulopathy and polycythaemia
are responsible for predisposing them to stroke.
Main mechanism behind these disorders is proposed to be secondary polycythaemia
, dehydration, lack of activity, and compact/tight dressing which predispose to thromboembolic phenomenon.1 Four main clinical manifestations of high altitude illnesses are acute mountain sickness (AMS), high-altitude retinopathy (HAR), high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE).2
The aetiopathogenesis of cor pulmonale in COPD patients is complex and includes several mechanism such as hypoxaemia, polycythaemia
, inflammation and endothelial dysfunction that promote pulmonary hypertension (15).
: an unusual presentation of multiple myeloma," BMJ Case Reports, vol.
(2007) Leucocytosis in polycythaemia
vera predicts both inferior survival and leukaemic transformation.
The most common (though rare) side effects are venous thrombosis in trans women due to oestrogens, and polycythaemia
(too many red blood cells) caused by androgens in trans men.
Vera presenting as Cerebral Venous Sinus Thrombosis-A Case Report.
Other potential risk factors for PPHN include perinatal asphyxia, polycythaemia
, acidosis and hypothermia.