Oegema explained about their work.Hydrolethalus syndrome is a rare genetic disorder characterized by severe birth defects (hydrocephalus, polydactyly
, cardio/pulmonary malformations) that result in stillbirth or early neonatal death.The majority of cases affect people of Finnish ancestry, where the incidence is roughly 1 in 20,000.
has been documented in humans (Wilson, 1896; Osborn, 1901; Dehus and Snyder, 1932; Nelson, 1963; Hoomick et al., 1983, 1991; Rivera et al., 1999; Theodorou et al., 2003) and wild mammals, although published observations for the latter are rare.
In uterus, As exposure is also associated with a number of birth malformations, including cleft lip and palate, polydactyly
, syndactyly, spina bifida, club foot, eye malformations, and hip joint dislocation (Nordstrom et al., 1979).
An analysis into the relationship between mother's age and babies born with MSS malformations (polydactyly
excluded) revealed that a greater majority of MSS malformations (69%) occurred in mothers aged between 20-29 year.
A 3-year-old boy with a history of autism, polydactyly
, and micrognathia was evaluated for snoring, witnessed apneas, and nasal airway obstruction.
(3.) Akin S: An unusual and non-classified central polydactyly
of the foot.
Extra digits, also known as polydactyly
, sometimes present as an isolated finding but of ten are part of a syndrome.
Limb anomalies included syndactyly and polydactyly
in one infant each, and length discrepancies in the second and third toes of two infants.
He did present with polydactyly
and simian creases.
* Partial thumb polydactyly
. An unusually wide nail with a bifid lunula should always be x-rayed if it is present at birth because this may reveal abnormal maturation of the distal phalanx.
of feet in infants of diabetic mothers: epidemiological test of a clinical hypothesis.
Both dysmorphic facial signs (microcephaly, palatoschizis, cataracts, ptosis, micrognathia) and limb abnormalities (syndactyly of the second and third toe, polydactyly
) occur in the patients.