Both MSCs and TAMs have very specific signatures of gene expression in the tumour microenvironment, these will be resolved using microarray analysis in the polyoma
middle T antigen (PyMT) mouse mammary tumour virus (MMTV) spontaneous model of breast cancer.
Factors impacting short- and long-term outcomes include donor and recipient characteristics, cold ischemia time, donor --recipient match, immune-suppression regimes, and infection with polyoma
Brain biopsies for the diagnosis of central nervous system infections caused by herpes simplex viruses, toxoplasmosis, and the JC polyoma
virus have become a rarity given the widespread use of highly sensitive PCR-based methods.
virus, for example, is a well-known contaminant of serum, but a positive PCR result from serum cannot determine whether there is replicating virus present, or merely DNA fragments.
In some fresh skin and HNC tumors we have detected by multiplex genotyping the DNA of some polyoma
and herpesviruses (EBV, HH7, HH8, MCV--unpublished personal data), but for the moment we cannot conclude that these viruses are causally-related with the analyzed tumors.
Progressive multifocal leukoencephalopathy (PML) is a life-threatening disease of the central nervous system caused by JC polyoma
For instance, viral infections, including BK polyoma
virus, which may be clinically silent, can elicit a TH1 response that involves many of the genes that also participate in the acute rejection phenomena (32).
Reduced metastasis of Polyoma
virus middle T antigen-induced mammary cancer in plasminogendeficient mice.
One child lost her graft because of polyoma
(BK) nephropathy and the other secondary to chronic allograft nephropathy.
It is caused by various opportunistic viral infections such as CMV, adenovirus, EBV, human herpes virus 8 (HHV-8), human herpes virus 6 (HHV-6), PVB19, and BK polyoma
Sironi et al., "Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma
middlesized T antigen: implications for the pathogenesis of opportunistic vascular tumors," Proceedings of the National Academy of Sciences of the United States of America, vol.
Abbreviations A[beta]: Amyloid beta AD: Alzheimer's disease IC: Immune complex (complexes) HMPV: Human metapnaumovirus MeV: Measles virus MFI: Median fluorescence intensity NMFI: Normalized median fluorescence intensity rN: Recombinant nucleocapsid protein rVP1: Recombinant major capsid protein VLP: Virus-like particle WUPyV: WU polyoma