polysomy


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polysomy

(ˈpɒlɪˌsəʊmɪ)
n
(Genetics) genetics the state of being polysomic
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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Noun1.polysomy - congenital defect of having one or more extra chromosomes in somatic cells
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References in periodicals archive ?
Although biological, this is probably more accurately described as a "high-level polysomy" rather than true gene amplification; the definition, nonetheless, correlates strongly with clinical outcome, including therapeutic response to tyrosine kinase inhibitors (20).
Polysomy 8 is one of such rare karyotypic abnormalities that define a distinct biological subgroup of myeloid hematopathologies.
Since chromosome 17 polysomy can lead to false-positive results, it should be taken into consideration during identification, and evaluation of this entity.
Low-grade duplication of H2N gene (3 to 4 copies/cell) is usually the result of chromosome 17 polysomy and is not usually in association with high-level overexpression.
Interestingly, a significant number of cases (21 of 28, 75%) ultimately reclassified into the HER2 FISH equivocal group exhibited an average CEP17 copy number of 3 or greater, which is the traditional cutoff used to define chromosome 17 polysomy. This proportion was much higher (17 of 49, 34.7%) as compared to cases ultimately reclassified as HER2 FISH positive with a concurrent CEP17 copy number of 3 or greater.
(8.) Fryns JP, Kleczkowska A, Petit P, van den Berghe H.X-chromosome polysomy in the female: personal experience and review of the Literature.
The definition of KS, as an inclusion criterion for this study, required the availability of a karyotype consisting of an X chromosome polysomy and at least one Y chromosome, either as a single lineage or as a mosaicism (7).
Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.
Furthermore, high polysomy or gene mutation has been reported to play a role in EGFR overexpression in non-small-cell lung cancers and in breast cancer [31-33].
They also observed polysomy of chromosomes 3, 4, 10, 13, 17, and 18 in one case.
CEP17 polysomy poses another dilemma in interpreting HER2 FISH results; in addition, an increased number of CEP17 signals are related to amplification of the centromeric region rather than to true polysomy [9, 10].
Caption: Figure 6: FISH analysis of resected abdominal mass: dual color probe (ZytoLight KRAS/CEN 12), demonstrating polysomy and isochromosome 12p (CEN 12: red; KRAS: green); magnification 1000x.