In the new research, which was published in the November 28 issue of Science Translational Medicine, patients treated with AAV2-GAD gene therapy expressed a distinct treatment-related metabolic brain network, providing a clinical benefit by inducing the formation of new polysynaptic
pathways connecting the STN to cortical motor regions.
Another common symptom in the case of lumbalgia is muscle contracture caused by a nociceptive reflex that goes on the exteroceptor polysynaptic
pathways, increasing the answer of the alpha motor neurons.
In light of the studies, pathophysiologic mechanisms are based on the sensitization in polysynaptic
pathways of the blink reflex and increased excitability in facial motor neurons (1).
This forms a photoperiodic response circuit, with the SCN projecting indirectly to the pineal gland through a chain of polysynaptic
connections that include the PVN.
In addition, a new study shows that the right hemisphere subcortical white matter and hippocampus injury is a risk factor of delirium symptoms. Basically, the causes of delirium are disruption of the central nervous system's polysynaptic
pathways and changes in the balance between excitatory and inhibitory amino acids. Therefore, delirium is indeed a 'disease' with clearly defined pathophysiological mechanism.
This reflex increases neuromuscular activity (25) and the recruitment of motor units through the activation of muscle spindles and polysynaptic
pathways that reciprocally inhibit the motor neurons of antagonist muscles (11,28).
(22), and localizes the topographically bilateral lateral caudal pons and/or bilateral lateral medulla and polysynaptic
Isa, "Lack of monosynaptic corticomotoneuronal EPSPs in rats: disynaptic EPSPs mediated via reticulospinal neurons and polysynaptic
EPSPs via segmental interneurons," Journal of Neurophysiology, vol.
Benzodiazepine decreases monosynaptic and polysynaptic
reflexes by increasing presynaptic GABA inhibition a similar action to Baclofen.
pathways modify the signals greatly and can cause complex reflex patterns e.g.
One way to assess the disorders of the sympathetic system is sympathetic skin response (SSR), which is a result of polysynaptic
reflex arch activation.
Darkness transmitted to the hypothalamic suprachiasmatic nuclei by the retinohypothalamic tract activates a polysynaptic
pathway, which leads to the release of noradrenaline and adenosine triphosphate (ATP) by the sympathetic nerve terminals that reach the pineal gland .