Tecovirimat (TPOXX) is an antiviral that inhibits a major envelope protein that poxviruses
need to produce extracellular virus.
Using systems biology, virology, cell biology, biochemistry, molecular biology and a wide range of microscopy approaches we will unravel the complex interactions between poxviruses
and the host cell degradation machinery.
like vaccinia virus, owing to their large genome size, can accommodate a large part of deletion in their genome without compromising their ability to replicate in the cells and can, therefore, insert a number of genes of foreign origin (~25 kb), leading to the production of multivalent vaccines (4,5).
(APV) are very large viruses spread worldwide in a variety of hosts.
are increasingly being used in biomedical research for a wide range of purposes.
Foot and Mouth Disease (FMD), Coronavirus and poxviruses
are just some of the threats that animals imported into the country can carry.
are supposed to have antagonistic mechanism to innate antiviral immunity a multi-stage process.
The Moredun Research Institute said: "The institute has undertaken work on poxviruses
of sheep and cattle for many years, but more recently has extended this to investigate squirrelpox virus which is nearly always fatal in red squirrels and associated with their significant decline in the UK.
Human infections caused by vaccinialike poxviruses
are the largest known group of animal DNA viruses.
Bernard Moss, at the US National Institutes of Health, where he continued his work on poxviruses
, viral vectors and recombinant virus construction as well as in the replication and egress of vaccinia virus.
They discuss innate antiviral responses in invertebrates and Toll-like receptors (TLR) in vertebrates, as well as the phylogenetic relationship of pathogen sensing, the downstream adaptor molecules, and the functional consequences; nucleic acid sensing pathways, alternative regulator mechanisms of TLR signaling RIG-I-like receptors, the contribution of LGP2 to antiviral immunity, mitochondrial immune signaling complex and DNA sensors, and the complexities of downstream signaling, the adaptor molecules involved, and the regulatory pathways; and the molecular mechanisms by which pathogens such as poxviruses
, HIV, and influenza evade host innate immune mechanisms, the viral virulence factors responsible, and their interactions with the innate immune sensors.