Using systems biology, virology, cell biology, biochemistry, molecular biology and a wide range of microscopy approaches we will unravel the complex interactions between poxviruses
and the host cell degradation machinery.
like vaccinia virus, owing to their large genome size, can accommodate a large part of deletion in their genome without compromising their ability to replicate in the cells and can, therefore, insert a number of genes of foreign origin (~25 kb), leading to the production of multivalent vaccines (4,5).
(APV) are very large viruses spread worldwide in a variety of hosts.
are increasingly being used in biomedical research for a wide range of purposes.
Foot and Mouth Disease (FMD), Coronavirus and poxviruses
are just some of the threats that animals imported into the country can carry.
are supposed to have antagonistic mechanism to innate antiviral immunity a multi-stage process.
Human infections caused by vaccinialike poxviruses
Bernard Moss, at the US National Institutes of Health, where he continued his work on poxviruses
, viral vectors and recombinant virus construction as well as in the replication and egress of vaccinia virus.
They discuss innate antiviral responses in invertebrates and Toll-like receptors (TLR) in vertebrates, as well as the phylogenetic relationship of pathogen sensing, the downstream adaptor molecules, and the functional consequences; nucleic acid sensing pathways, alternative regulator mechanisms of TLR signaling RIG-I-like receptors, the contribution of LGP2 to antiviral immunity, mitochondrial immune signaling complex and DNA sensors, and the complexities of downstream signaling, the adaptor molecules involved, and the regulatory pathways; and the molecular mechanisms by which pathogens such as poxviruses
, HIV, and influenza evade host innate immune mechanisms, the viral virulence factors responsible, and their interactions with the innate immune sensors.
Washington, August 20 ( ANI ): New research from scientists at Fred Hutchinson Cancer Research Center and collaborating institutions has uncovered how poxviruses
includes smallpox evolve to rapidly adapt against host defenses - despite their low mutation rates.
are among the most dangerous viruses for the human species.
FGI-101-1A6 is a fully-human, monoclonal antibody targeting a host protein, TSG101, which is uniquely exposed on the surface of cells infected with viruses, such as influenza, HIV and poxviruses