practolol


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practolol

(ˈpræktəˌlɒl)
n
(Pharmacology) a beta-blocker with formula C14H22N2O3, formerly used to treat cardiac arrhythmia, but now largely withdrawn due to severe side-effects
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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In this field, commonly used analysis methods include proportional ADR reporting ratio, reporting odds ratio, Bayesian Confidence Propagation Neural Network (BCPNN), empirical Bayesian Gamma Poisson Shrinker, etc .[sup][4] The WHO's Uppsala International Drug Monitoring Collaboration Center used BCPNN to analyze, by which they identified a number of ADRs, such as identification of acidosis and esophagitis as the most common adverse reaction of alendronate sodium and confirmation the association between pericarditis and practolol.[sup][4]
Cardiosseletivos Nao seletivos Drogas com atividade al antagonista adicional Acebutolol * Alprenolol * Bucindolol Atenolol Carteolol * Carvedilol Betaxolol Nadolol Labetalol Bevantolol Oxprenolol * Bisoprolol Penbutolol * Celiprolol Pindolol * Esmolol Propranolol Metoprolol Sotalol Practolol * Timolol Quadro 4: Criterios usados na selecao e forma de obtencao dos dados.
Treatment of hypertension following endotracheal intubation--A study comparing the efficacy of labetalol, practolol and placebo.
Of the estimated 5,000 analogs synthesized to address the inherent carcinogenicity of pronethalol, 47 were marketed, with practolol and atenolol being regarded as the parent drugs of modern [beta]1 antagonists.
Wardell (1978a), for example, estimated that practolol, a drug in the beta-blocker family, could save ten thousand lives a year if approved in the United States.
Exactly this situation existed when the FDA prohibited physicians from prescribing practolol and alprenolol even though large clinical studies indicated that these drugs could reduce the mortality rate of heart attack patients by 40 percent.
* Beta blockers (e.g., acebutolol, atenolol, labetalol, metoprotolol, oxprenolol, pindolol, practolol, and propranolol)
There are many variations on this story: isoproterenol inhalers, used to relieve asthma, caused 3500 deaths in England and Wales in the sixties; practolol, an anti-hyper-intensive, caused a number of cases of permanent or near-permanent blindness in England in the seventies.
The secondary form has been reported in associated with a history of previous abdominal surgery or peritonitis, prolonged use of practolol, chronic ambulatory peritoneal dialysis, ventriculoperitoneal shunts, intraperitoneal instillation of drugs, sarcoidosis, SLE, liver cirrhosis, hysteromyomas, ovarian endometriotic cyst or tumor, and tuberculous etiology.
Drug hypersensitivity may result from agents such as verapamil, quinacrine, etodolac, mepacrine, proguanil, mexiletine, methyldopa, lithium, venlafaxine, gold, fluorouracil, bleomycin, hydroxyurea, practolol and doxorubicin.
The exact aetiology of this entity (also called 'scerosing encapsulating peritonitis') is by and large unknown (the idiopathic/primary variety of cocoon), but at times, cocoon formation can occur secondary to a variety of conditions (secondary cocoon) like drugs (practolol, propranolol), chronic ambulatory peritoneal dialysis, ventriculoperitoneal shunts, diseases such as sarcoidosis, SLE, liver cirrhosis, uterine leiomyomas, endometriotic cysts or tumours of the ovary, etc.