ARBITER: Arterial Biology for Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin
on carotid intima medial thickness.
They emphasize that, with the exception of one study in which new cancer diagnoses were more frequent on pravastatin
than on a sugar pill, all large prospective randomized statin trials have shown no difference in the risk of cancer among people taking statins versus those taking a sugar pill.
Researchers recently analyzed previously published data that followed a randomized trial of pravastatin
(Pravachol[R]) in 9,000 patients in New Zealand.
One small study looked at the effect of Pravachol (pravastatin
), a drug used to lower cholesterol (abstract 77).
The scientists randomly assigned half the volunteers to get the standard dose of the anticholesterol drug pravastatin
or an elevated dose of the more potent statin drug atorvastatin.
When drugs become necessary, we recommend as initial therapy pravastatin
or atorvastatin for elevated low-density lipoprotein cholesterol levels and gemfibrozil or fenofibrate when triglyceride concentrations exceed 500 mg/dL."
CHICAGO -- Three years of treatment with pravastatin
failed to slow age-related cognitive decline in the first large clinical trial aimed at examining statin therapy's effects specifically in the elderly.
We've also been able to show that cholesterol-lowering drugs like pravastatin
reduce hs-CRP levels.
You start him on pravastatin
(Pravachol) 20 mg once daily.
They'll test the effectiveness of a heart drug, Pravastatin
, which may also help prevent strokes.
(1) The increased risk was similar for lipophilic (pravastatin
, rosuvastatin) and hydrophilic (atorvastatin, simvastatin, lovastatin) statins, although the analysis wasn't adjusted for doses used.
15 in Annals of Internal Medicine (doi:10.7326/M13-2942), found that the average portion of days covered under prescribed statin therapy was 77% for patients started on generic lovastatin, pravastatin
, or simvastatin, and 71% for patients started on name brands of these medications (P < .001).