Although the risk of CRC in UC patients is thought to increase with disease duration and extent, this may not have been the case in some centres where early colectomy was provided for patients with severe diseases in an attempt to control their symptoms early on in the disease course, especially in the prebiological
Examples abound: prebiological
molecules bathed in energy were selected in soupy seas to become the building blocks of life; certain kinds of amino-acid bonding were favored while others were excluded, implying that the evolutionary steps toward life yielded new states more thermodynamically stable than their precursor molecules.
(38) Most derive their views by considering only one or two types of evidence: sophisticated calculations of the amino acid sequences of truly ancient proteins, the repertoire of amino acids found in meteorites; simulations of an early, prebiological
planet Earth; and so on.
"One of the problems with early biology on the early Earth is you need abundant nitrogen for all these prebiological
processes to happen - and of course nitrogen is in ammonia.
Many mysteries of this prebiological
history of the universe have been progressively unlocked by rational inquiry, especially mathematical inquiry into the universe's patterns and structures.
If life arose in organic form, then there must have been a prebiological
source of organics.
In the generalisation of the use of the algorithm (selection among equally probable variants) discovered by Darwin and soon to become, in its application to prebiological
and cosmological evolution, "omnivorous" (according to the definition of Dennett himself, 1995), lies the reason for the evolution of Darwinism itself from a scientific model to a fully fledged philosophy of chance and necessity.
(5.) Clays are surprisingly complex and may have played a cooperative role with catalytic peptides in an intermediate stage of prebiological
chemistry preceding the emergence of life on earth (Rao et al 1980).
Their work, which appears in the April 2 EMBO JOURNAL, supports the hypothesis of a prebiological
"RNA world," in which RNA molecules assembled and copied themselves, acting almost as independent living things.