preclinical phase


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Related to preclinical phase: preclinical trial, preclinical study
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Noun1.preclinical phase - a laboratory test of a new drug or a new invasive medical device on animal subjects; conducted to gather evidence justifying a clinical trial
trial, run, test - the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial"
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References in periodicals archive ?
Benefitting the growth in subcontracting of non-core purposes, improved abilities of preclinical CROs, the global preclinical CRO market has been principally helped to offer supplementary value-added services, rolling number of drugs in the preclinical phase, economies of production & scale, mutual advantage to the contractor as well as the client and high R&D expenditure.
For projects for common indications the goal is out-licensing in preclinical phase. A subset of compounds under NeuroVive's NVP015 program has been licenced to Fortify Therapeutics, a BridgeBio company, for local treatment development of Leber's Hereditary Optic Neuropathy (LHON).
M2 PHARMA-June 26, 2019-Onxeo Expands its Pipeline with New Optimized Lead OX401 Entering Proof-of-Concept Preclinical Phase
NORDIC BUSINESS REPORT-June 21, 2019-Onxeo commences proof-of-concept preclinical phase for optimised lead candidate OX401
Global Banking News-June 21, 2019-Onxeo commences proof-of-concept preclinical phase for optimised lead candidate OX401
M2 EQUITYBITES-June 21, 2019-Onxeo commences proof-of-concept preclinical phase for optimised lead candidate OX401
The Cystinosis Research Foundation provided financial support for the preclinical phase of the program.
While acknowledging that the root cause of Alzheimer's are unknown, and probably multifactorial, the paper hypothesized a pathophysiologic time line beginning with three-stage preclinical phase: Stage 1: Asymptomatic cerebral amyloidosis: amyloid positive PET brain imaging with an amyloid-binding ligand and/or a cerebrospinal fluid assay with low-amyloid-beta 42 in the presence of normal cognition.
already during the so-called preclinical phase) and that it very sensitively reflects the course of the disease and enables predictions on future developments.
Identifying these individuals would enable developing a plan for intervention aimed at the preclinical phase of AD, when treatments would be more effective.
While acknowledging that the root causes of Alzheimer's are unknown, and probably multifactorial, the paper hypothesized a pathophysiologic time line beginning with a three-stage preclinical phase:
Frost and coauthors as an interesting tool for screening preclinical Alzheimer disease since they report changes in pupil flash response in this preclinical phase of the condition.