In the resting state, ReHo values were significantly elevated in the posterior cingulate cortex, medial frontal lobe, inner side cortex of the prefrontal lobe
, and part of the parietal lobe of normal elderlies and aMCI patients (P<0.05, Figures 1 and 2).
They stimulate the premotor and parietal cortex area in the brain - sensory movements in games that require real-time action - and the prefrontal lobe
, which controls decision-making.
 Furthermore, the research team found that there were regional connectivity abnormalities in the bilateral superior medial prefrontal lobe
, left superior temporal gyrus(STG), left paracentral lobule, right precentral lobule, and right inferior parietal lobe of the AOS patients by utilizing the regional homogeneity (ReHo) analysis, proposing to use the combination of ReHo values in the medial prefrontal lobe
, left superior temporal gyrus, and right inferior parietal lobe as biomarkers (sensitivity of 88.24%, specificity of 91.89% and accuracy of 90.14%) for AOS patients.
In that regard, the core function of the prefrontal lobe
is to get an acceptable justification for limbic impulses.
This result is consistent with the literature showing that the frontal lobe, especially the lateral inferior prefrontal lobe
, is the "social part" of the human brain, which deals with social relationships and functions critically in empathy.
The prefrontal lobe
doesn't develop fully until we're twenty-five.
In the same line, Magno and Allan (2007) found activity changes within areas of the medial prefrontal lobe
and medial posterior cingulate when the retrieval was associated with the self.
Lobotomy involved severing connections in the brain's prefrontal lobe
with an implement resembling an icepick (a leucotome).
In motor imagery, left hemispheric ERD patterns were dominant in the first three bands, except for a bilateral high [alpha] ERD pattern in the prefrontal lobe
, similar to the one observed for NAV but of lower intensity.
Findings from structural and functional brain imaging studies have suggested that intelligence as well as attentional control processes of working memory each depends heavily on neural circuitry of the prefrontal lobe
This theory is also reinforced by later research (Buckholtz et al., 2010) which linked the impulsivity which is prevalent in psychopathy with dysfunction in the dopamine reward circuitry which includes the nucleus accumbens, hippocampus, amygdala, ventral tegmental area and the prefrontal lobe
. This research supports these findings of abnormal functioning in the prefrontal cortex, specifically the orbitofrontal cortex/OFC, dorsolateral prefrontal cortex/DLPFC, ventrolateral prefrontal cortex/VLPFC, and the medial prefrontal cortex/MPFC) and psychopathic behaviors.
This is the first published human study to enhance prefrontal lobe
function using direct electrical stimulation, the researchers report.