pregnenolone


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pregnenolone

(prɛɡˈnɛnəˌləʊn)
n
(Biochemistry) a steroid precursor to steroid hormones
References in periodicals archive ?
One of the most powerful things that I did for my recovery, seven years after I got sick, was to begin taking pregnenolone, DHEA and progesterone for adrenal gland support, along with bio-identical thyroid hormone.
Loneliness is linked to the decrease of a neurosteroid called pregnenolone, which improves stress-related disorders and calms the hyper-vigilance in the brain caused by social threats.
We identify these brain problems by low levels of hormones (estradiol, testosterone, progesterone, pregnenolone, Cortisol, and thyroid) as well as vitamins and minerals (especially D and the B vitamins, zinc, and magnesium).
[USPRwire, Fri Oct 12 2018] Rockville, US, 2018-Oct-12 -- /EPR Network/ -- Pregnenolone also known as 3-alpha-hydroxy-5-beta-pregnen-20-one acts as a precursor for DHEA, progesterone, estrogen, testosterone and cortisol.
[ClickPress, Fri Oct 12 2018] Pregnenolone also known as 3-alpha-hydroxy-5-beta-pregnen-20-one acts as a precursor for DHEA, progesterone, estrogen, testosterone and cortisol.
[UKPRwire, Fri Oct 12 2018] Pregnenolone also known as 3-alpha-hydroxy-5-beta-pregnen-20-one acts as a precursor for DHEA, progesterone, estrogen, testosterone and cortisol.
Severe pain has serious physiological effects on the endocrine system caused by the stimulation of the HPA system, which in turn results in elevated serum ACTH, cortisol, and pregnenolone levels.
The disease is caused by biallelic mutations in the CYP17A1 gene, encoding the enzyme 17[alpha]-hydroxyprogesterone (OHP) aldolase (Cytochrome P450c17) catalyzing the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione ([DELTA]4A) via 17[alpha]-hydroxylation and the 17,20-lyase reaction.
The review article quoted (3) describes a conference abstract that provided APPI vs APCI comparison data for only testosterone, progesterone, pregnenolone, and dehydroepiandroterone (DHEA).
The MCCB scores of other drugs such as AL-108, Armodafinil, MK0777 and Pregnenolone showed no significant differences between the drug-treated group and the control group.
The cholesterol is first imported into the mitochondria by steroidogenic acute regulatory protein (StAR), and cytochrome P450 side chain cleavage enzyme (CYP11A1) then cleaves the side-chain of cholesterol to produce pregnenolone [1].
The steroid hormones analyzed included pregnenolone, 17a-hydroxyprogesterone, and corticosterone, which are produced in the zona glomerulosa (ZG) and zona fasciculate (ZF), as well as dehydroepiandrosterone (DHEA), androstenedione, and free testosterone of the zona reticularis (ZR) of the adrenal cortex.