The common neurobehavioural manifestations include seizure-like episodes which are often resistant to anticonvulsive treatment, myoclonus, confusion, headaches, hallucinations, stroke-like episodes, coma, impairment of cognitive function, mood swings, focal neurological deficits, disturbance of consciousness, presenile dementia
, psychosis, and ataxia [1, 2].
Studies like this one are important because there is little research on presenile dementia
The first case of FD with a pure and presenile dementia
without either extrapyramidal symptoms or metabolic abnormalities has been reported by Modrego and coworkers.
According to the diagnostic criteria of the Chinese Classification of Mental Disorders, third edition (CCMD-3) (1)--a national classification and diagnostic system widely used by psychiatrists in China--AD dementia is divided into 3 subtypes: senile dementia, presenile dementia
, and mixed dementia.
The regulatory change comes after an Institute of Medicine (IOM) study found "sufficient evidence of an association" between moderate or severe TBI and Parkinsonism; dementias (which VA understands to include presenile dementia
of the Alzheimer type and post-traumatic dementia); depression (which also was associated with mild TBI); and diseases of hormone deficiency that may result from hypothalamo-pituitary changes.
Disability Classification Timeframe Unprovoked seizures moderate or severe N/A (diagnosed) Parkinson's moderate or severe N/A Dementia (1) moderate or severe within 15 years Depression mild within 12 months Depression moderate or severe within three years Diseases of hormone moderate or severe within 12 months deficiency (2) (1) Specific to presenile dementia
of the Alzheimer type and post-traumatic dementia (2) Specific to diseases that result from hypothalamo-pituitary changes
NHD, also known as polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy (PLOSL/ MIM221770), is an autosomal recessive disease characterized by association of presenile dementia
and destruction of bones.
Hairdressers, bank tellers, dentists, pest control workers, physicians, photographic process machine workers, supervisory cleaning and building service workers, post-secondary teachers, and clergy face greater risk of presenile dementia