Various antiepileptics have been implicated as causing factors of DILE, including phenytoin, trimethadione, primidone
, ethosuximide, clobazam, valproic acid, and carbamazepine (CBZ) (1, 4).
The patient did not benefit from propranolol (80 mg/day), primidone
(250 mg/day), and gabapentin (900 mg/day).
We also excluded participants with previous history of cardiovascular disease (angina, myocardial infarction, coronary artery revascularization surgery, stroke, and congestive heart failure) and all patients using drugs that can interfere with thyroid function, such as amiodarone, carbamazepine, carbidopa, phenytoin, furosemide, haloperidol, heparin, interferon, levodopa, lithium, metoclopramide, propranolol, primidone
, rifampicin, and valproic acid (15).
Propranolol and primidone
, together with establishing essential drug treatments, often have inadequate efficacy (1).
Two medications - the beta blocker propranolol and the epilepsy drug primidone
- can reduce tremors by 10-30%, but they work only in about half of patients.
Many antiepileptic drugs (AEDs), including carbamazepine, ethosuximide, fosphenytoin, phenobarbital, phenytoin, primidone
, topiramate, and valproate, are potentially teratogenic.
He had difficulty when he went for job interviews because he constantly worried about reaching out to shake hands with a new employer and "missing their hand." After failed treatment with first-line medications, propranolol and primidone
, his grandfather was determined to help him and began researching online, where he discovered information about FUS.
If ET is affecting your quality of life, blood pressure medications known as beta blockers--usually propranolol (Inderal[R])--or the anti-seizure medication primidone
(Mysoline[R]) may be prescribed.
He was taking the anticonvulsant primidone
to manage essential tremors.
For patients taking an anticonvulsant drug that induces hepatic enzymes (carbamazepine, phenytoin or primidone
), the initial dose of lamotrigine is 50 mg once daily, titrating upward to 100 mg once daily at the third week, 200 mg once daily at the fifth week, 300 mg once daily at the sixth week, and 400 mg once daily at the seventh week.