Given its potential nephrotoxicity and potential preexisting renal compromise in this patient population, lower doses (0.25-1mg/kg/ once/week versus traditional 3-5mg/kg/week), administration through an intravesical route via urethral catheter (invasive), or combination with probenecid
, have all been proposed to reduce potential renal injury.
If you can't tolerate either of the XOIs, your physician may prescribe the uricosuric drug probenecid
, which lowers uric acid by increasing its excretion by the kidneys.
In a retrospective study in which the treatment methods of gout were evaluated, a NSAII was used at the rate of 41.7%, colchicine 16.7%, corticosteroid 21%, probenecid
1.4%, and allopurinol 31.8%, and 39% of the patients reported that they did not receive any treatment (5).
The World Anti-Doping Agency list also includes probenecid
, 5[alpha] reductase inhibitors, diuretics and ketoconazole .
In the second trial, known as sulopenem for resistant enterobacteriaceae, or SURE 2, IV sulopenem followed by oral sulopenem etzadroxil combined with probenecid
in a bilayer tablet will be compared to IV ertapenem followed by oral ciprofloxacin in adults with complicated urinary tract infections.
Available US Food and Drug Administration (FDA)-approved options for lowering sUA include xanthine oxidase inhibitors (allopurinol and febuxostat) that prevent production of uric acid; a uricosuric agent (probenecid
) that increases uric acid output in urine; and a uric acid-specific enzyme (pegloticase) that converts uric acid to allantoin.
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid
. Int J Cancer 2005;116:824-829.
Medication causing decreased renal elimination (aminoglycosides, cyclosporine, nonsteroidal anti-inflammatory agents, sulfonamides, probenecid
, salicylates, penicillin, colchicine, cisplatin, and other nephrotoxic drugs) and drugs causing displacement of methotrexate from its protein-binding sites (salicylates, probenecid
, sulfonamides, barbiturates, phenytoin, retinoids, sulfonylureas, and tetracyclines) significantly increase its toxicity.
Barbhaiya, "Pharmacokinetic Interactions of Cefprozil With Food, Propantheline, Metoclopramide, and Probenecid
in Healthy Volunteers," The Journal of Clinical Pharmacology, vol.
, a Panx1 inhibitor, protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity .
IV amikacin and cefoxitin with probenecid
were started, and intravenous ampicillin/sulbactam was discontinued.
Homovanillic acid and 5-hydroxyindoleacetic acid cerebrospinal fluid levels: a study with and without probenecid
administration of their relationship to the state of consciousness after head injury.