procarbazine


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pro·car·ba·zine

 (prō-kär′bə-zēn)
n.
A potent antineoplastic drug, C12H19N3O, used in its hydrochloride form in combination with other drugs to treat advanced Hodgkin lymphoma.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

procarbazine

(prəʊˈkɑːbəˌziːn)
n
(Pharmacology) a drug used in the treatment of cancer, esp lymphomas
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.procarbazine - an antineoplastic drug used to treat Hodgkin's disease
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

procarbazine

n procarbazina
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Procarbazine (Capsule 50mg), Proguanil (Tablets 100mg), Propylthiouracil (Tablets 50mg), Rituximab (Injection 100mg/10ml, 500mg/50ml), Spectinomycin (Injection 2gram), Thioguanine Solid (Oral Dosage Form 40mg), Trastuzumab (Injection 40mg and 60mg).
In the course of time, he received multiple lines of chemotherapy including doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD), bleomycin, etoposide, doxorubicin, cyclo-phosphamide, vincristine, procarbazine, prednisone (BEACOPP) and dexamethasone, cisplatin, cytarabine (DHAP).
6, did an exhaustive research on 289 patients diagnosed with anaplastic OD and their response to radiotherapy (RT) alone compared to RT with procarbazine, lomustine, and vincristine (PCV) chemotherapy with the conclusion that PCV with RT did not prolong survival.6 Jenkins et al.,then through sequencing and following up 119 patients, predicted a better overall survival of approximately one year for patients with low grade OD featuring 1p/19q co-deletion or translocation, especially those who received higher doses of RT.7 Van den Brent et al., also conducted a major study in 2006 with a total of 368 patients with anaplastic OD enrolled and followed up for a median of 60 months.8
According to US Food and Drug Administration, few drugs have been used as antioxidants for pro-oxidant activity i.e., procarbazine, motexan gadolinium, elesclomol, 2-methoxyestradiol, imexon, minodronate and histamine (Gupta et al., 2012).
Men who receive cytotoxic chemotherapy with alkylating agents, such as cyclophosphamide and procarbazine, or radiotherapy to the testes are at greater risk of testicular dysfunction than those who receive other agents or modalities (Green et al., 2014; Jacob, Barker, Goodman, & Holmes, 1998).
In 2013, he had been given a diagnosis of stage IV Hodgkin lymphoma, for which he underwent several chemotherapy sessions, including ABVD (adriamycin, bleomycin, vinblastine, dacarbazine); DHAP (dexamethasone, high-dose cytarabin, cisplatin); ICE (ifosfamide, carboplatin, etoposide); ChIVPP (chlorambucil, vinblastine, procarbazine, prednisolone); etoposide, gemcitabine, liposomal doxorubicin plus methylprednisolone; and brentuximab plus bendamustin.
The patient was given six cycles of an intravenous high-dose methotrexate-based regimen (methotrexate 3.5 gm/[m.sup.2], vincristine 2 mg/[m.sup.2], procarbazine 100 mg/[m.sup.2], and cytarabine 100 mg/[m.sup.2] (post-radiation)) followed by consolidation therapy of one cycle of whole-brain radiotherapy (40 Gy to the whole brain, 2 Gy/day x 20 days).
Features of the patients who developed post-transplant solid organ malignancies Age at Primary Oncologic Diagnosis Tx, years diagnosis Sex diagnosis time 1 Tyrosinemia F Kaposi 36 1 BA F Burkitt's lymphoma 60 1 BA F Liver sarcoma 24 1 BA M Hodgkin's lymphoma 60 7 BA F Cutaneous lymphoma 60 2 BA E Kaposi 30 Age at Malignancy Tx, years Immunosuppression treatment Prognosis 1 Tacrolimus Radiotherapy Alive 1 Tacrolimus Died before starting Died treatment 1 Tacrolimus Imatinib mesilat Alive 1 Tacrolimus Cyclophosphamide, Alive vincristine, prednisolone, procarbazine 7 Tacrolimus Cyclophosphamide, Alive vincristine, prednisolone, procarbazine 2 Tacrolimus Radiotherapy Alive BA: biliary atresia; F: female; M: male
2009, NL Rel-3 yr OS 70% retrospective [28] (HDCT) HDCT: high-dose chemotherapy, TBI: total body irradiation, CR: complete response, PR: partial response, PBSC: peripheral blood stem cell, BSC: bone marrow stem cell, SCT: stem cell transplant, EFS: event-free survival, OS: overall survival, NF: not listed, M: melphalan, V: vincristine, E: etoposide, C: carboplatin, B: busulfan, P: procarbazine, I: ifosphamide, A: adriamycin, D: doxorubicin, ES: Ewing's sarcoma, rel: relapsed, RP.SA: response present, specifics unavailable, RFS: relapse-free survival, EFT: Ewing's family of tumors, and ES rel: patients with relapsed ES that got HDCT.
Jenkins et al., "Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH," Journal of Clinical Oncology, vol.
PCV (Procarbazine, CCNU, and Vincristine) chemotherapy and radiation therapy of the craniospinal axis were planned.