prodrug

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pro·drug

(prō′drŭg′)

Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

prodrug

(ˈprəʊˌdrʌɡ)

(Biochemistry) a compound that is itself biologically inactive but is metabolized in the body to produce an active therapeutic drug

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

pro•drug

(ˈproʊˌdrʌg)

n.

an inactive substance that is converted to a drug within the body by the action of enzymes or other chemicals.

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References in periodicals archive ?

KP879 is KemPharm's prodrug product candidate which is also based on SDX and intended for the treatment of Stimulant Use Disorder.

KemPharm enters into license agreement with Gurnet Point Capital affiliate

TLANDO, a novel oral prodrug of testosterone containing testosterone undecanoate, is designed to help restore normal testosterone levels in hypogonadal men.

Lipocine to Present at the Canaccord Genuity 39th Annual Growth Conference

NB1111 is Nemus'proprietary prodrug of tetrahydrocannabinol (THC) that is currently in development for the treatment of glaucoma.

Pii Inks Devt. Deal with Nemus

LPCN 1144, an oral prodrug of bioidentical testosterone, is being developed as a treatment of non-alcoholic steatohepatitis and is currently being studied in a proof-of-concept MRI PDFF based liver fat imaging clinical study.

Lipocine Completes Successful Ex Vivo Conversion Assessment of Tlando

In a movement to develop less-toxic anticancer drugs, recent attention has been focused on the use of prodrugs. A prodrug remains inactive until it reaches diseased cells at which time it becomes activated and cytotoxic.

Synthesis and Characterization of trans-Dichlorotetrakis (imidazole)cobalt(III) Chloride: A New Cobalt(III) Coordination Complex with Potential Prodrug Properties

Tumor-tropic neural stem cells (NSCs) have been engineered to localize a variety of therapeutic agents to invasive brain tumors [1], with NSC-mediated enzyme prodrug treatment strategy being the first to be tested clinically.

Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy

Pharmacologists neutralized this property by attaching a small peptide to create a prodrug called Mipsagargin, which responds to enzymes released by some types of cancer cells.

The life-saving potential of the deadly carrot

The company's lead product candidate Mipsagargin, a novel prodrug therapeutic for cancer, is being developed initially for hepatocellular carcinoma, or liver cancer.

Inspyr Therapeutics to Acquire US Biotech Lewis and Clark Pharmaceuticals

(VTGN) said that the European Patent Office (EPO) has issued a notice of intention to grant the company's patent application for its oral CNS prodrug candidate in Phase 2 development for major depressive disorder (MDD).

European Patent for major depressive disorder treatment

A prodrug is a modified biologically active compound that will release the active compound in vivo following enzymatic or chemical cleavage.

A Stability-Indicating RP-HPLC-UV Method for Determination and Chemical Hydrolysis Study of a Novel Naproxen Prodrug

As presented in Figures 2 and 3, all examined compounds inhibited the activity of AChE; however, prodrug 2 only inhibited up to 21.2% at a concentration of 3 [micro]mol/mL.